Document Detail

LMR spectroscopy: a new sensitive method for on-line recording of nitric oxide in breath.
MedLine Citation:
PMID:  10066726     Owner:  NLM     Status:  MEDLINE    
Laser magnetic resonance spectroscopy (LMRS) is a sensitive and isotope-selective technique for determining low concentrations of gaseous free radicals with high time resolution. We used this technique to analyze the nitric oxide (NO) concentration profile while simultaneously measuring the flow and expired volume during several single breathing cycles. Eight healthy, nonallergic volunteers were investigated. An initial NO peak was found in all breathing cycles before the NO concentration dropped to a relatively stable plateau in the late phase of expiration. The nasal NO peak was significantly higher than the oral NO peak. The nasal NO plateau was always higher than the oral NO plateau. The height of the initial nasal and oral NO peak rose with increasing duration of breath hold, whereas the late expiratory NO plateau changed only little for either the nasal or the oral breathing cycles. Our findings demonstrate, in line with other reports using other techniques, that the nose is the primary source for NO within the airways.
P Mürtz; L Menzel; W Bloch; A Hess; O Michel; W Urban
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  86     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-05-07     Completed Date:  1999-05-07     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1075-80     Citation Subset:  IM    
Institut für Angewandte Physik der Universität Bonn, D-53115 Bonn.
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MeSH Terms
Breath Tests / instrumentation*
Magnetic Resonance Spectroscopy
Nasal Cavity / metabolism
Nitric Oxide / analysis*
Online Systems
Respiratory Mechanics / physiology
Reg. No./Substance:
10102-43-9/Nitric Oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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