Document Detail

LINAC radiosurgery in recurrent Cushing's disease after transsphenoidal surgery: a series of 5 cases.
MedLine Citation:
PMID:  14968397     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Oversecretion of ACTH from pituitary adenomas is associated with morbidity and reduced life expectancies. We hypothesized that radiosurgical treatment may provide effective tumour and hormonal control associated with minimal pituitary insufficiency. METHOD: Data of five patients who underwent LINAC radiosurgery for recurrent or residual Cushing's disease between 1999 and 2002 were prospectively collected. RESULT: Follow-up period ranged from 27 to 49 months (mean 38 months). All patients attained remission in 6-18 months (mean 8.4 months). One patient (20 %) developed biochemical recurrence 12 months after remission. One patient (20 %) developed hydrocortisone deficiency 24 months after radiosurgery. None of the patients had new visual field defect detected on follow-up. CONCLUSION: In this small case series, LINAC radiosurgery was shown to be an effective and safe treatment of persistent or recurrent Cushing's disease following transsphenoidal surgery. Long-term follow-up and larger patient series is recommended for further clarification.
G K Wong; C H Leung; K W Chiu; R Ma; C S Cockram; M J Lam; W S Poon
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Minimally invasive neurosurgery : MIN     Volume:  46     ISSN:  0946-7211     ISO Abbreviation:  Minim Invasive Neurosurg     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2004-02-17     Completed Date:  2004-05-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9440973     Medline TA:  Minim Invasive Neurosurg     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  327-30     Citation Subset:  IM    
Division of Neurosurgery, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China.
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MeSH Terms
Adenoma / complications,  surgery*
Cushing Syndrome / etiology*,  surgery*
Follow-Up Studies
Middle Aged
Pituitary Neoplasms / complications,  surgery*
Prospective Studies
Sphenoid Bone / surgery*
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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