| LIM-domain-only proteins in cancer. | |
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MedLine Citation:
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PMID: 23303138 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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LIM-domain proteins are a large family of proteins that are emerging as key molecules in a wide variety of human cancers. In particular, all members of the human LIM-domain-only (LMO) proteins, LMO1-4, which are required for many developmental processes, are implicated in the onset or the progression of several cancers, including T cell leukaemia, breast cancer and neuroblastoma. These small proteins contain two protein-interacting LIM domains but little additional sequence, and they seem to function by nucleating the formation of new transcriptional complexes and/or by disrupting existing transcriptional complexes to modulate gene expression programmes. Through these activities, the LMO proteins have important cellular roles in processes that are relevant to cancer such as self-renewal, cell cycle regulation and metastasis. These functions highlight the therapeutic potential of targeting these proteins in cancer. |
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Authors:
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Jacqueline M Matthews; Krystal Lester; Soumya Joseph; David J Curtis |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-10 |
Journal Detail:
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Title: Nature reviews. Cancer Volume: - ISSN: 1474-1768 ISO Abbreviation: Nat. Rev. Cancer Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101124168 Medline TA: Nat Rev Cancer Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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School of Molecular Bioscience, The University of Sydney, New South Wales 2006, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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