Document Detail

LIF and CNTF, which share the gp130 transduction system, stimulate hepatic lipid metabolism in rats.
MedLine Citation:
PMID:  8843746     Owner:  NLM     Status:  MEDLINE    
We determined the effects of leukemia inhibitory factor (LIF) and ciliary neurotrophic factor (CNTF) on lipid metabolism in intact rats. Administration of LIF and CNTF increased serum triglycerides in a dose-dependent manner with peak values at 2 h. The effects of LIF and CNTF on serum cholesterol were very small, and serum glucose was unaffected. Both LIF and CNTF stimulated hepatic triglyceride secretion, hepatic de novo fatty acid synthesis, and lipolysis. Pretreatment with phenylisopropyl adenosine, which inhibits lipolysis, partially inhibited LIF- and CNTF-induced hypertriglyceridemia. Interleukin-4, which inhibits cytokine-induced hepatic fatty acid synthesis, also partially inhibited LIF- and CNTF-induced hypertriglyceridemia. These results indicate that both lipolysis and de novo fatty acid synthesis play a role in providing fatty acids for the increase in hepatic triglyceride secretion. Neither indomethacin nor adrenergic receptor antagonists affected the hypertriglyceridemia. The combination of LIF plus CNTF showed no additive effects consistent with the action of both cytokines through the gp130 transduction system. Thus LIF and CNTF have similar effects on lipid metabolism; they join a growing list of cytokines that stimulate hepatic triglyceride secretion and may mediate the changes in lipid metabolism that accompany the acute phase response.
K Nonogaki; X M Pan; A H Moser; J Shigenaga; I Staprans; N Sakamoto; C Grunfeld; K R Feingold
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  271     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1996-12-05     Completed Date:  1996-12-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E521-8     Citation Subset:  IM    
Department of Medicine, University of California, San Francisco 94143, USA.
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MeSH Terms
Ciliary Neurotrophic Factor
Growth Inhibitors / pharmacology*
Leukemia Inhibitory Factor
Lipid Metabolism*
Liver / metabolism*
Lymphokines / pharmacology*
Lysosome-Associated Membrane Glycoproteins
Membrane Glycoproteins / metabolism*
Nerve Tissue Proteins / pharmacology*
Rats, Sprague-Dawley
Signal Transduction / drug effects*
Grant Support
Reg. No./Substance:
0/Ciliary Neurotrophic Factor; 0/Growth Inhibitors; 0/Interleukin-6; 0/Lamp1 protein, rat; 0/Leukemia Inhibitory Factor; 0/Lymphokines; 0/Lysosome-Associated Membrane Glycoproteins; 0/Membrane Glycoproteins; 0/Nerve Tissue Proteins

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