| LIF and CNTF, which share the gp130 transduction system, stimulate hepatic lipid metabolism in rats. | |
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MedLine Citation:
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PMID: 8843746 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We determined the effects of leukemia inhibitory factor (LIF) and ciliary neurotrophic factor (CNTF) on lipid metabolism in intact rats. Administration of LIF and CNTF increased serum triglycerides in a dose-dependent manner with peak values at 2 h. The effects of LIF and CNTF on serum cholesterol were very small, and serum glucose was unaffected. Both LIF and CNTF stimulated hepatic triglyceride secretion, hepatic de novo fatty acid synthesis, and lipolysis. Pretreatment with phenylisopropyl adenosine, which inhibits lipolysis, partially inhibited LIF- and CNTF-induced hypertriglyceridemia. Interleukin-4, which inhibits cytokine-induced hepatic fatty acid synthesis, also partially inhibited LIF- and CNTF-induced hypertriglyceridemia. These results indicate that both lipolysis and de novo fatty acid synthesis play a role in providing fatty acids for the increase in hepatic triglyceride secretion. Neither indomethacin nor adrenergic receptor antagonists affected the hypertriglyceridemia. The combination of LIF plus CNTF showed no additive effects consistent with the action of both cytokines through the gp130 transduction system. Thus LIF and CNTF have similar effects on lipid metabolism; they join a growing list of cytokines that stimulate hepatic triglyceride secretion and may mediate the changes in lipid metabolism that accompany the acute phase response. |
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Authors:
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K Nonogaki; X M Pan; A H Moser; J Shigenaga; I Staprans; N Sakamoto; C Grunfeld; K R Feingold |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 271 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1996 Sep |
Date Detail:
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Created Date: 1996-12-05 Completed Date: 1996-12-05 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: E521-8 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of California, San Francisco 94143, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Ciliary Neurotrophic Factor Growth Inhibitors / pharmacology* Interleukin-6* Leukemia Inhibitory Factor Lipid Metabolism* Liver / metabolism* Lymphokines / pharmacology* Lysosome-Associated Membrane Glycoproteins Male Membrane Glycoproteins / metabolism* Nerve Tissue Proteins / pharmacology* Rats Rats, Sprague-Dawley Signal Transduction / drug effects* |
| Grant Support | |
ID/Acronym/Agency:
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DK-40990/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Ciliary Neurotrophic Factor; 0/Growth Inhibitors; 0/Interleukin-6; 0/Lamp1 protein, rat; 0/Leukemia Inhibitory Factor; 0/Lymphokines; 0/Lysosome-Associated Membrane Glycoproteins; 0/Membrane Glycoproteins; 0/Nerve Tissue Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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