| LGALS3BP, lectin galactoside-binding soluble 3 binding protein, induces vascular endothelial growth factor in human breast cancer cells and promotes angiogenesis. | |
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MedLine Citation:
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PMID: 22864925 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Elevated serum or tissue levels of lectin galactoside-binding soluble 3 binding protein (LGALS3BP) have been associated with short survival and development of metastasis in a variety of human cancers. However, the role of LGALS3BP, particularly in the context of tumor-host relationships, is still missing. Here, we show that LGALS3BP knockdown in MDA-MB-231 human breast cancer cells leads to a decreased adhesion to fibronectin, a reduced transendothelial migration and, more importantly, a reduced expression of vascular endothelial growth factor (VEGF). Production of VEGF, that was restored by exposure of silenced cells to recombinant LGALS3BP, required an intact PI3k/Akt signaling. Furthermore, we show that LGALS3BP was able to directly stimulate HUVEC tubulogenesis in a VEGF-independent, galectin-3-dependent manner. Immunohistochemical analysis of human breast cancer tissues revealed a correlation among LGALS3BP expression, VEGF expression, and blood vessel density. We propose that in addition to its prometastatic role, LGALS3BP secreted by breast cancer cells functions critically as a pro-angiogenic factor through a dual mechanism, i.e by induction of tumor VEGF and stimulation of endothelial cell tubulogenesis. |
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Authors:
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Enza Piccolo; Nicola Tinari; Daniela Semeraro; Sara Traini; Imma Fichera; Albana Cumashi; Rossana La Sorda; Francesca Spinella; Anna Bagnato; Rossano Lattanzio; Maurizia D'Egidio; Annalisa Di Risio; Pavlos Stampolidis; Mauro Piantelli; Clara Natoli; Axel Ullrich; Stefano Iacobelli |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-5 |
Journal Detail:
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Title: Journal of molecular medicine (Berlin, Germany) Volume: - ISSN: 1432-1440 ISO Abbreviation: J. Mol. Med. Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-8-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9504370 Medline TA: J Mol Med (Berl) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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MediaPharma s.r.l., Via Colle dell'Ara, Chieti, Italy, e.piccolo@unich.it. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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