Document Detail


LDP-02 (Millenium).
MedLine Citation:
PMID:  11566006     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Millennium (formerly LeukoSite) and Genentech are developing LDP-02, a humanized monoclonal antibody to the alpha4beta7 integrin receptor on leukocytes, for potential use in the treatment of inflammatory bowel diseases (IBD), such as Crohn's disease and ulcerative colitis [274580]. LeukoSite intended to develop iv and sc formulations of LDP-02 for acute IBD [315156]. In December 1997, Genentech entered into a collaboration with LeukoSite to develop and commercialize LDP-02 for the treatment of IBD [275395], [279420]. A phase II SBIR grant was awarded to LeukoSite in September 1996. The US $750,000 grant was used to develop LDP-02 and to conduct preclinical tests on the antibody for the treatment of IBD [218689]. In February 1999, Lehman Brothers predicted the drug had a 10% probability of reaching market. Assuming a successful launch, Lehman Brothers analysts estimated peak sales would occur in 2011 with sales at that time of US $250 million [319225].
Authors:
J K Marshall
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in investigational drugs (London, England : 2000)     Volume:  2     ISSN:  1472-4472     ISO Abbreviation:  Curr Opin Investig Drugs     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-09-21     Completed Date:  2001-12-04     Revised Date:  2011-08-01    
Medline Journal Info:
Nlm Unique ID:  100965718     Medline TA:  Curr Opin Investig Drugs     Country:  England    
Other Details:
Languages:  eng     Pagination:  502-4     Citation Subset:  IM    
Affiliation:
Department of Medicine, McMaster University, Hamilton, Ontario, Canada. marshallj@mcmaster.ca
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies, Monoclonal / adverse effects,  metabolism,  therapeutic use*
Clinical Trials as Topic
Colitis, Ulcerative / therapy*
Crohn Disease / therapy*
Humans
Integrins / immunology*
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Integrins; 0/LDP-02 monoclonal antibody; 0/integrin alpha4beta7

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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