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LDL lowering in peripheral arterial disease: are there benefits beyond reducing cardiovascular morbidity and mortality?
MedLine Citation:
PMID:  22707981     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Peripheral arterial disease affecting the lower extremities is associated with increased mortality due to cardiovascular events and reduced functional capacity due to claudication. There is abundant evidence to support the role of lipid lowering with statins in preventing cardiovascular events in patients with peripheral arterial disease. Over the last 10 years, multiple studies have been designed to test the theory that LDL C lowering with statins could result in improved exercise performance in patients with peripheral arterial disease. However, this remains an active area of investigation to better understand how the pleiotropic effects of statins could lead to enhanced functional capacity for patients with claudication. Furthermore, new insights into the complex pathophysiology of claudication may help us to understand the potential role of lipid lowering therapy in alleviating exercise induced symptoms.
Authors:
Amy W Pollak; Christopher M Kramer
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Clinical lipidology     Volume:  7     ISSN:  1758-4302     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-6-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101502551     Medline TA:  Clin Lipidol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  141-149     Citation Subset:  -    
Affiliation:
Department of Medicine & the Cardiovascular Imaging Center, University of Virginia Health System, University of Virginia, Lee Street, Box 800170, Charlottesville, VA 22908, USA.
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