| LDL lowering in peripheral arterial disease: are there benefits beyond reducing cardiovascular morbidity and mortality? | |
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MedLine Citation:
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PMID: 22707981 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Peripheral arterial disease affecting the lower extremities is associated with increased mortality due to cardiovascular events and reduced functional capacity due to claudication. There is abundant evidence to support the role of lipid lowering with statins in preventing cardiovascular events in patients with peripheral arterial disease. Over the last 10 years, multiple studies have been designed to test the theory that LDL C lowering with statins could result in improved exercise performance in patients with peripheral arterial disease. However, this remains an active area of investigation to better understand how the pleiotropic effects of statins could lead to enhanced functional capacity for patients with claudication. Furthermore, new insights into the complex pathophysiology of claudication may help us to understand the potential role of lipid lowering therapy in alleviating exercise induced symptoms. |
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Authors:
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Amy W Pollak; Christopher M Kramer |
Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Clinical lipidology Volume: 7 ISSN: 1758-4302 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-6-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101502551 Medline TA: Clin Lipidol Country: - |
Other Details:
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Languages: ENG Pagination: 141-149 Citation Subset: - |
Affiliation:
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Department of Medicine & the Cardiovascular Imaging Center, University of Virginia Health System, University of Virginia, Lee Street, Box 800170, Charlottesville, VA 22908, USA. |
Export Citation:
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Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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