| LDL-cholesterol lowering or HDL-cholesterol raising for cardiovascular prevention. A lesson from cholesterol turnover studies and others. | |
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MedLine Citation:
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PMID: 16310198 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A number of reports have indicated that both lowering low density lipoprotein (LDL)-cholesterol and raising high density lipoprotein (HDL)-cholesterol can result in significant cardiovascular benefit, both in terms of reduction of events and also, to a variable extent, of atheromatous lesions. LDL and HDL have opposite roles in body cholesterol regulation and, in theory, both reduced deposition (LDL reduction) and increased removal (raised HDL) can improve vascular disease. A number of reports over the last 30 years have attempted to quantitate with cholesterol balance/turnover studies, the correlations between LDL and HDL levels and body cholesterol pool sizes. More recently, these studies have evaluated the effects of LDL or HDL changes on cholesterol elimination. Data have, at times, been fully consistent with theoretical expectations, whereas at others they have not. Evaluation of these, at times, historical data provides, however, an important clue to the understanding of current results with different medications for the management of lipoprotein disorders. |
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Authors:
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Cesare R Sirtori; Remo Fumagalli |
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Publication Detail:
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Type: Journal Article; Review Date: 2005-11-28 |
Journal Detail:
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Title: Atherosclerosis Volume: 186 ISSN: 0021-9150 ISO Abbreviation: Atherosclerosis Publication Date: 2006 May |
Date Detail:
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Created Date: 2006-04-03 Completed Date: 2006-09-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
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Languages: eng Pagination: 1-11 Citation Subset: IM |
Affiliation:
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Department of Pharmacological Sciences, University of Milano, Via Balzaretti, 20133 Milano, Italy. cesare.sirtori@unimi.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anticholesteremic Agents
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therapeutic use* Cardiovascular Diseases / blood, prevention & control* Cholesterol, HDL / blood*, drug effects Cholesterol, LDL / blood*, drug effects Humans Prognosis |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 0/Cholesterol, HDL; 0/Cholesterol, LDL |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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