Document Detail

LDL S-homocysteinylation decrease in chronic kidney disease patients undergone lipid lowering therapy.
MedLine Citation:
PMID:  22659373     Owner:  NLM     Status:  Publisher    
The dyslipidemia control through lipid lowering therapy is one of the targets for the treatment of CKD. By this pilot study we aimed to evaluate the effect of hypolipidemic drugs on the levels of low molecular weight (LMW) thiols bound to LDL in nephropatic patients. We enrolled thirty CKD randomized to receive three different hypolipidemic regimens: simvastatin alone (40 mg/day) or ezetimibe/simvastatin combined therapy (10/20 or 10/40 mg/day). LMW thiols in their reduced and total form, oxidative stress indices as malondialdehyde and allantoin/uric acid ratio were evaluated. LDL thiolation decreased in all treated patients, but a greater efficacy was attained from a combined therapy with a higher simvastatin dose, by which a 31% decrease of all S-bound thiols was reached after one year of therapy. In particular, in this patients group the reduction of apoB-Hcy was greater than 40%. The concomitant decrease of the oxidative stress indices during the therapy brings to the hypothesis that decreased levels of protein bound thiols may be a consequence of oxidative stress improvement. Therefore lipid lowering therapy may have beneficial effects also through the reduction of LDL-S-homocysteinylation that has been reported to have antiangiogenic and proatherogenic effect on endothelial vascular cells.
Angelo Zinellu; Salvatore Sotgia; Elisabetta Pisanu; Giacomina Loriga; Luca Deiana; Andrea Ercole Satta; Ciriaco Carru
Related Documents :
19299803 - General health and knee function outcomes from 7 days to 12 weeks after spinal anesthes...
20839683 - A rapid recovery program: early home and pain free.
21507143 - Procalcitonin-guidance for reduction of antibiotic use in low-risk outpatients with com...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-30
Journal Detail:
Title:  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences     Volume:  -     ISSN:  1879-0720     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-6-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9317982     Medline TA:  Eur J Pharm Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier B.V.
Dept. Biomedical Sciences, University of Sassari, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Determination of permeability coefficients of ophthalmic drugs through different layers of porcine, ...
Next Document:  Consumption of a High-Fat Diet During Pregnancy Decreases the Activity of Cytochrome P450 3a in the ...