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LDL Particle Size and Reactive Oxygen Metabolites in Dyslipidemic Patients.
MedLine Citation:
PMID:  22448308     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Small dense low-density lipoprotein (sdLDL) which has a small LDL particle size with greater susceptibility to oxidation is regarded as a risk marker for cardiovascular disease. The diacron reactive oxygen metabolites (d-ROMs) test has recently been introduced as an oxidative stress-related marker in the clinic. The aim of the present study was to investigate the correlation between the mean LDL particle size and the oxidative stress status as evaluated by the d-ROMs in dyslipidemic patients.
METHODS: The study included 278 dyslipidemic patients (121 male and 157 female, mean age, 60 years). Clinical data including the conventional atherosclerotic risk factors in addition to the mean LDL particle size measured with the gel electrophoresis and the d-ROMs were collected.
RESULTS: Male patients had a significantly smaller mean LDL particle size than females (262.2 ± 7.5 [SD] vs. 264.3 ± 6.7 Å, P<0.05), while female patients had a significantly higher d-ROMs level than males (318 ± 68 vs. 350 ± 72 U. Carr., P<0.01). A multiple regression analysis revealed that there was an independent, significant, and inverse correlation between the mean LDL particle size and the d-ROMs (β=-0.19, P<0.05).
CONCLUSIONS: These findings of the co-existence of both markers suggest that sdLDL and oxidative stress can be cooperative in atherogenesis, possibly leading to the incidence of CVD, in dyslipidemic patients.
Authors:
Kazuhiko Kotani; Kokoro Tsuzaki; Nobuyuki Taniguchi; Naoki Sakane
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of preventive medicine     Volume:  3     ISSN:  2008-8213     ISO Abbreviation:  Int J Prev Med     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-26     Completed Date:  2012-10-02     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101535380     Medline TA:  Int J Prev Med     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  160-6     Citation Subset:  -    
Affiliation:
Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto.
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