| LDL-C/HDL-C Ratio Predicts Carotid Intima-Media Thickness Progression Better Than HDL-C or LDL-C Alone. | |
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MedLine Citation:
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PMID: 21773051 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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High-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) are strong predictors of atherosclerosis. Statin-induced changes in the ratio of LDL-C to HDL-C (LDL-C/HDL-C) predicted atherosclerosis progression better than LDL-C or HDL-C alone. However, the best predictor of subclinical atherosclerosis remains unknown. Our objective was to investigate this issue by measuring changes in carotid intima-media thickness (IMT). A total of 1,920 subjects received health examinations in 1999, and were followed up in 2007. Changes in IMT (follow-up IMT/baseline IMT × 100) were measured by ultrasonography. Our results showed that changes in IMT after eight years were significantly related to HDL-C (inversely, P < 0.05) and to LDL-C/HDL-C ratio (P < 0.05). When the LDL-C/HDL-C ratios were divided into quartiles, analysis of covariance showed that increases in the ratio were related to IMT progression (P < 0.05). This prospective study demonstrated the LDL-C/HDL-C ratio is a better predictor of IMT progression than HDL-C or LDL-C alone. |
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Authors:
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Mika Enomoto; Hisashi Adachi; Yuji Hirai; Ako Fukami; Akira Satoh; Maki Otsuka; Shun-Ichi Kumagae; Yasuki Nanjo; Kuniko Yoshikawa; Eishi Esaki; Eita Kumagai; Kinuka Ogata; Akiko Kasahara; Eri Tsukagawa; Kanako Yokoi; Kyoko Ohbu-Murayama; Tsutomu Imaizumi |
Publication Detail:
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Type: Journal Article Date: 2011-07-05 |
Journal Detail:
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Title: Journal of lipids Volume: 2011 ISSN: 2090-3049 ISO Abbreviation: J Lipids Publication Date: 2011 |
Date Detail:
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Created Date: 2011-07-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101553819 Medline TA: J Lipids Country: Egypt |
Other Details:
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Languages: eng Pagination: 549137 Citation Subset: - |
Affiliation:
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Division of Cardio-Vascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, Kurume 830-0011, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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