Document Detail


LDH isozymes in transplantable hamster tumours with different histogenesis and differentiation.
MedLine Citation:
PMID:  7271428     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
LDH isozymes were assayed by polyacrylamide gel electrophoresis in 6 long-term transplantable skin tumours in Syrian hamsters. The percentages of the M-subunits were as follows: in a slow growing fibrosarcoma with abortive differentiation and producing lung metastases -- 63.3; in two well differentiated squamous cell carcinomas with moderate growth -- 79.8 and 74.9; in a slow growing and metastasizing melanotic melanoma -- 67.7; in undifferentiated amelanotic and depigmented melanomas with very fat growth -- 72.8 and 77.4. Therefore no consistent relationship has emerged between histogenesis, growth rate, differentiation and metastases of the studied neoplasms from one side and their LDH isozyme pattern -- on the other.
Authors:
I G Nicolov; I N Chernozemsky; T Petkova-Bocharova; I I Stoichev
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archiv für Geschwulstforschung     Volume:  51     ISSN:  0003-911X     ISO Abbreviation:  Arch. Geschwulstforsch.     Publication Date:  1981  
Date Detail:
Created Date:  1981-10-14     Completed Date:  1981-10-14     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0372411     Medline TA:  Arch Geschwulstforsch     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  174-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Carcinoma, Squamous Cell / enzymology
Cell Line
Cricetinae
Female
Fibrosarcoma / enzymology
Isoenzymes
L-Lactate Dehydrogenase / metabolism*
Male
Melanoma / enzymology
Mesocricetus
Neoplasm Staging
Neoplasm Transplantation
Neoplasms, Experimental / enzymology
Skin Neoplasms / enzymology*,  pathology
Chemical
Reg. No./Substance:
0/Isoenzymes; EC 1.1.1.27/L-Lactate Dehydrogenase

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