Document Detail


LDH isoenzymes in CSF in the diagnosis of neonatal brain damage.
MedLine Citation:
PMID:  3766114     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lactate dehydrogenase isoenzymes in cerebrospinal fluid were measured during the first 24 h of life in 25 asphyctic neonates. The infants were subjected to clinical and developmental examinations for a mean follow-up period of 15.2 months. The mean values for cerebrospinal LDH2(MH3) and LDH3(M2H2) isoenzymes were significantly higher in asphyctic infants who died from hypoxic-ischemic encephalopathy or who survived but suffered neurologic sequelae, than they were in those asphyctic infants who survived and were normal in the follow-up studies. Therefore, the authors conclude that the lactate dehydrogenase isoenzyme pattern in cerebrospinal fluid may be of value when assessing anoxic brain damage.
Authors:
F Fernández; J Quero; A Verdú; M C Ferreiros; E Daimiel; M C Roche
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  74     ISSN:  0001-6314     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  1986 Jul 
Date Detail:
Created Date:  1986-11-19     Completed Date:  1986-11-19     Revised Date:  2006-08-16    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  30-3     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Asphyxia Neonatorum / cerebrospinal fluid,  complications*
Brain Damage, Chronic / cerebrospinal fluid*,  etiology
Follow-Up Studies
Humans
Infant
Infant, Newborn
Isoenzymes
L-Lactate Dehydrogenase / cerebrospinal fluid*
Prognosis
Chemical
Reg. No./Substance:
0/Isoenzymes; EC 1.1.1.27/L-Lactate Dehydrogenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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