Document Detail

LC: clinical syndrome in different primaries.
MedLine Citation:
PMID:  9696359     Owner:  NLM     Status:  MEDLINE    
Leptomeningeal carcinomatosis (LC) occurs in solid tumors like breast, lung carcinoma and melanoma, rarely sarcoma and in leukemia and lymphoma. Clinical symptoms of LC often present with differential diagnostic problems. The most common presentation are multiple neuraxis syndromes which for didactic reasons are classically considered as central nervous system (CNS), spinal (SP) or cranial nerve (CN) symptoms and signs and appear isolated or more frequently in combinations. It is generally agreed that signs are usually more prominent than symptoms. Only few series focus on monolocular presentation at clinical manifestation. This overview describes the clinical symptoms and signs in patients with LC, the concept of multiple neuraxis lesions, CNS, CN and SP signs and symptoms. Also the problem of new symptoms and signs in patients treated with antineoplastic chemotherapy and radiation is addressed. The study is based on own results and a survey of the present literature.
G Wolfgang; D Marcus; S Ulrike
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of neuro-oncology     Volume:  38     ISSN:  0167-594X     ISO Abbreviation:  J. Neurooncol.     Publication Date:    1998 Jun-Jul
Date Detail:
Created Date:  1998-10-21     Completed Date:  1998-10-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8309335     Medline TA:  J Neurooncol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  103-10     Citation Subset:  IM    
Neurologic Department Kaiser Franz Josef Spital, Vienna, Austria.
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MeSH Terms
Breast Neoplasms / pathology*
Cranial Nerves / physiopathology
Diagnosis, Differential
Lung Neoplasms / pathology*
Melanoma / pathology*
Meningeal Neoplasms / diagnosis*,  secondary*,  therapy
Spinal Cord / physiopathology
Stomach Neoplasms / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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