| LATE assessment of thrombolytic efficacy with alteplase (rt-PA) six-24 hours after onset of acute myocardial infarction. | |
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MedLine Citation:
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PMID: 8141717 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Conflicting results on the benefit of thrombolytic therapy administered six to 24 hours after the onset of myocardial infarction (MI) led to the LATE trial. Five thousand seven hundred and eleven patients were treated with recombinant tissue plasminogen activator (t-PA) or placebo, treatment was begun between six and 24 hours after the onset of infarction. For patients treated within 12 hours, there was a relative reduction in 35 day mortality of 25%, but no benefit for those treated at 12 to 24 hours. The benefits were confined to those whose treatment was begun within three hours of admission to hospital. These results widen the window for effective treatment from six to 12 hours after the onset of infarction, but emphasise the need for expeditious treatment when the diagnosis of MI is suspected. |
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Authors:
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J H Bett |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Australian and New Zealand journal of medicine Volume: 23 ISSN: 0004-8291 ISO Abbreviation: Aust N Z J Med Publication Date: 1993 Dec |
Date Detail:
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Created Date: 1994-04-26 Completed Date: 1994-04-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 1264322 Medline TA: Aust N Z J Med Country: AUSTRALIA |
Other Details:
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Languages: eng Pagination: 745-8 Citation Subset: IM |
Affiliation:
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Cardiology Department, Prince Charles Hospital, Brisbane, Qld. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Double-Blind Method Humans Myocardial Infarction / drug therapy* Thrombolytic Therapy* Time Factors Tissue Plasminogen Activator / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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EC 3.4.21.68/Tissue Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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