Document Detail

LASIK and dry eye.
MedLine Citation:
PMID:  17540125     Owner:  NLM     Status:  MEDLINE    
Dry eye is one of the most common complications after laser-assisted in situ keratomileusis (LASIK). The clinical signs of post-LASIK dry eye include positive vital staining of ocular surface, decreased tear film breakup time and Schirmer test, reduced corneal sensitivity, and decreased functional visual acuity. The symptoms and signs last at least 1 month after LASIK. Although the mechanisms for developing post-LASIK dry eye are not completely understood, loss of corneal innervation by flap-making may affect the reflex loops of the corneal-lacrimal gland, corneal-blinking, and blinking-meibomian gland, and blinking-meibomian gland, resulting in decreased aqueous and lipid tear secretion and mucin expression. As LASIK enhancement by flap-lifting induces less dry eye symptoms and signs than first surgery, it is suggested that other factors rather than loss of neurotrophic effect may be involved in the mechanisms of post-LASIK dry eye. The treatments of dry eye include artificial tears, topical cyclosporine, hot compress, punctal plugs, and autologous serum eye drops. For patients with severe preoperative dry eye, a combination of punctal plugs and serum eye drops is required to be used before surgery.
Ikuko Toda
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Comprehensive ophthalmology update     Volume:  8     ISSN:  1527-7313     ISO Abbreviation:  Compr Ophthalmol Update     Publication Date:    2007 Mar-Apr
Date Detail:
Created Date:  2007-06-01     Completed Date:  2007-07-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100910750     Medline TA:  Compr Ophthalmol Update     Country:  United States    
Other Details:
Languages:  eng     Pagination:  79-85; discussion 87-9     Citation Subset:  IM    
Minamiaoyama Eye Clinic, Tokyo, Japan.
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MeSH Terms
Cyclosporine / administration & dosage,  therapeutic use
Dry Eye Syndromes / etiology*,  physiopathology,  therapy
Keratomileusis, Laser In Situ / adverse effects*,  methods
Occlusive Dressings
Ointments / therapeutic use
Ophthalmic Solutions / therapeutic use
Prostheses and Implants
Surgical Flaps / adverse effects
Time Factors
Visual Acuity
Reg. No./Substance:
0/Ointments; 0/Ophthalmic Solutions; 59865-13-3/Cyclosporine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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