Document Detail


L6 skeletal muscle cells have functional V1-vasopressin receptors coupled to stimulated inositol phospholipid metabolism.
MedLine Citation:
PMID:  2947815     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of vasopressin and related peptides upon the rat skeletal muscle cell line, L6, have been examined. No effects upon cellular cyclic AMP levels were found indicating that L6 cells possess no functional V2-vasopressin receptors. Vasopressin and its analogues did, however, stimulate the rapid and dose-dependent accumulation of inositol phosphates. This effect and the rank order of potency of vasopressin analogues demonstrate the presence of functional V1-vasopressin receptors upon L6 cells. These results suggest that the L6 line may be a useful model for vasopressin effects upon skeletal muscle metabolism.
Authors:
M J Wakelam; S Patterson; M R Hanley
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  FEBS letters     Volume:  210     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  1987 Jan 
Date Detail:
Created Date:  1987-02-19     Completed Date:  1987-02-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  181-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Line
Inositol Phosphates / metabolism*
Kinetics
Muscles / metabolism*
Rats
Receptors, Angiotensin / metabolism*
Receptors, Vasopressin
Structure-Activity Relationship
Sugar Phosphates / metabolism*
Vasopressins / metabolism*,  pharmacology
Chemical
Reg. No./Substance:
0/Inositol Phosphates; 0/Receptors, Angiotensin; 0/Receptors, Vasopressin; 0/Sugar Phosphates; 11000-17-2/Vasopressins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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