Document Detail

L6 myoblast proliferation in response to muscle-derived extracts and serum from exercise-trained rats.
MedLine Citation:
PMID:  1878977     Owner:  NLM     Status:  MEDLINE    
Serum and skeletal muscle-derived extracts (MDE) were bioassayed for their ability to promote [3H]thymidine incorporation in L6 myoblasts to determine if exercise-training increases mitogenic growth factor activity. Rats were trained by climbing a 60 cm vertical grid with progressively greater weight for 7 and 28 days. Serum from 7 day trained rats and vastus MDE from 7 and 28 day trained rats, but not rectus femoris MDE, had increased mitogenic activity compared to serum and MDE from untrained rats. These data suggest that exercise may increase mitogenic growth factors in some skeletal muscles.
J A Chromiak; D R Mulvaney; C H Rahe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cell biology international reports     Volume:  15     ISSN:  0309-1651     ISO Abbreviation:  Cell Biol. Int. Rep.     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-10-03     Completed Date:  1991-10-03     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7708050     Medline TA:  Cell Biol Int Rep     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  335-44     Citation Subset:  IM; S    
Interdepartmental Physiology Program, Auburn University, Alabama 36849.
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MeSH Terms
Cell Division
Growth Substances / blood,  metabolism
Mitogens / blood,  metabolism
Muscle Development
Muscles / cytology*,  metabolism
Physical Conditioning, Animal
Physical Exertion / physiology*
Thymidine / metabolism
Reg. No./Substance:
0/Growth Substances; 0/Mitogens; 50-89-5/Thymidine

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