Document Detail


L2pB1: a new player in autoimmunity.
MedLine Citation:
PMID:  21195478     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
L2pB1 cells (PD-L2positive B1 cells) are a newly discovered subpopulation of B1 B cells. L2pB1 cells are noted for the expression of PD-L2 (CD273, B7-DC), a ligand for the inhibitory receptor PD-1, which distinguishes this subpopulation from other B1 B cells that lack PD-L2, namely, L2nB1 cells (PD-L2negative B1 cells). PD-L2 gene expression is regulated differently in B1 B cells as compared to macrophages and dendritic cells. L2pB1 cells share many commonly known B1 cell features with L2nB1 cells. These include spontaneous IgM secretion, constitutive ERK activation, elevated co-stimulatory molecule expression, skewing of T cell differentiation, and unique proliferative responsiveness (to LPS, PMA, but not anti-IgM). However, L2pB1 cells express a biased Ig repertoire that is enriched for self-reactivity as compared with L2nB1 cells. Further, L2pB1 cells present antigen more potently than L2nB1 cells. In addition, L2pB1 cells switch Ig isotype more readily from IgM to IgG1 and IgG2b upon cytokine stimulation. Moreover, increased numbers of L2pB1 cells are present in murine models of lupus and this correlates with increased serum anti-dsDNA titers. These characteristics suggest that L2pB1 cells may play a pathophysiological role in autoimmune dyscrasias. In this report we review the special features of L2pB1 cells and how they may contribute to autoimmunity.
Authors:
Xuemei Zhong; Thomas L Rothstein
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2010-12-31
Journal Detail:
Title:  Molecular immunology     Volume:  48     ISSN:  1872-9142     ISO Abbreviation:  Mol. Immunol.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-30     Completed Date:  2011-08-10     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  7905289     Medline TA:  Mol Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1292-300     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Hematology and Oncology Section, Department of Medicine, Boston University Medical Center, Boston, MA, USA. xuemei.zhong03@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigens, CD80 / immunology*
Autoantigens / immunology
Autoimmunity*
B-Lymphocyte Subsets / immunology*
Humans
Lymphocyte Activation / immunology
Mice
Programmed Cell Death 1 Ligand 2 Protein
RNA, Double-Stranded / immunology
T-Lymphocytes / immunology
Th17 Cells / immunology
Grant Support
ID/Acronym/Agency:
AI029690/AI/NIAID NIH HHS; AI60896/AI/NIAID NIH HHS; R03 AR059908-01/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, CD80; 0/Autoantigens; 0/PDCD1LG2 protein, human; 0/Pdcd1lg2 protein, mouse; 0/Programmed Cell Death 1 Ligand 2 Protein; 0/RNA, Double-Stranded
Comments/Corrections

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