Document Detail

L-tyrosine ameliorates some effects of lower body negative pressure stress.
MedLine Citation:
PMID:  7716196     Owner:  NLM     Status:  MEDLINE    
Tyrosine, a large neutral amino acid normally present in protein foods, is the precursor of the catecholamine neurotransmitters dopamine, norepinephrine, and epinephrine. Animal studies indicate that systemic administration of tyrosine in pharmacological quantities can reduce physiological and behavioral decrements induced by highly stressful conditions. The current study was designed to test the effects of tyrosine (100 mg/kg of body weight) on humans exposed to cardiovascular stress. Twenty participants were exposed to two Lower Body Negative Pressure (LBNP) sessions (-50 mm Hg for a maximum of 30 min) during each of two testing sessions of a repeated measure double-blind placebo-controlled study. The detected effects of tyrosine include an overall increase in pulse pressure (LBNP typically reduces pulse pressure) and an increase in auditory event related potential amplitude (P300-N300), an electro-physiological correlate of attention which may indicate enhanced cognitive activation.
A B Dollins; L P Krock; W F Storm; R J Wurtman; H R Lieberman
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Physiology & behavior     Volume:  57     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-05-17     Completed Date:  1995-05-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  223-30     Citation Subset:  IM; S    
Massachusetts Institute of Technology, Department of Brain and Cognitive Sciences, Cambridge 02139, USA.
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MeSH Terms
Affect / drug effects
Cardiac Output / drug effects
Cross-Over Studies
Double-Blind Method
Electrocardiography / drug effects
Electroencephalography / drug effects
Electromyography / drug effects
Heart Rate / drug effects
Hydrocortisone / blood
Lower Body Negative Pressure / adverse effects*
Psychomotor Performance / drug effects
Stress, Physiological / physiopathology*,  psychology
Stroke Volume / drug effects
Tyrosine / pharmacology*
Ventricular Function, Left / drug effects
Reg. No./Substance:
50-23-7/Hydrocortisone; 55520-40-6/Tyrosine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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