Document Detail

L-type calcium channel blockade attenuates morphine withdrawal: in vivo interaction between L-type calcium channels and corticosterone.
MedLine Citation:
PMID:  18177874     Owner:  NLM     Status:  MEDLINE    
Both opioids and calcium channel blockers could affect hypothalamic-pituitary-adrenal (HPA) axis function. Nifedipine, as a calcium channel blocker, can attenuate the development of morphine dependence; however, the role of the HPA axis in this effect has not been elucidated. We examined the effect of nifedipine on the induction of morphine dependency in intact and adrenalectomized (ADX) male rats, as assessed by the naloxone precipitation test. We also evaluated the effect of this drug on HPA activity induced by naloxone. Our results showed that despite the demonstration of dependence in both groups of rats, nifedipine is more effective in preventing of withdrawal signs in ADX rats than in sham-operated rats. In groups that received morphine and nifedipine concomitantly, naloxone-induced corticosterone secretion was attenuated. Thus, we have shown the involvement of the HPA axis in the effect of nifedipine on the development of morphine dependency and additionally demonstrated an in vivo interaction between the L-type Ca2+ channels and corticosterone.
Saeed Esmaeili-Mahani; Yadollah Fathi; Fereshteh Motamedi; Farhad Hosseinpanah; Abolhassan Ahmadiani
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-11-13
Journal Detail:
Title:  Hormones and behavior     Volume:  53     ISSN:  0018-506X     ISO Abbreviation:  Horm Behav     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-03-03     Completed Date:  2008-05-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0217764     Medline TA:  Horm Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  351-7     Citation Subset:  IM    
Department of Biology, Faculty of Sciences, Shahid Bahonar University, Kerman, Iran.
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MeSH Terms
Calcium Channel Blockers / pharmacology*
Calcium Channels, L-Type / drug effects,  metabolism*
Corticosterone / physiology*
Drug Interactions
Hypothalamo-Hypophyseal System / drug effects,  metabolism,  physiopathology
Morphine / administration & dosage
Morphine Dependence / metabolism,  prevention & control*
Naloxone / pharmacology
Narcotic Antagonists / pharmacology
Narcotics / administration & dosage
Nifedipine / pharmacology*
Pituitary-Adrenal System / drug effects,  metabolism,  physiopathology
Rats, Wistar
Substance Withdrawal Syndrome / metabolism,  physiopathology,  prevention & control*
Reg. No./Substance:
0/Calcium Channel Blockers; 0/Calcium Channels, L-Type; 0/Narcotic Antagonists; 0/Narcotics; 21829-25-4/Nifedipine; 465-65-6/Naloxone; 50-22-6/Corticosterone; 57-27-2/Morphine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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