| L-serine in disease and development. | |
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MedLine Citation:
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PMID: 12534373 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The amino acid L-serine, one of the so-called non-essential amino acids, plays a central role in cellular proliferation. L-Serine is the predominant source of one-carbon groups for the de novo synthesis of purine nucleotides and deoxythymidine monophosphate. It has long been recognized that, in cell cultures, L-serine is a conditional essential amino acid, because it cannot be synthesized in sufficient quantities to meet the cellular demands for its utilization. In recent years, L-serine and the products of its metabolism have been recognized not only to be essential for cell proliferation, but also to be necessary for specific functions in the central nervous system. The findings of altered levels of serine and glycine in patients with psychiatric disorders and the severe neurological abnormalities in patients with defects of L-serine synthesis underscore the importance of L-serine in brain development and function. This paper reviews these recent insights into the role of L-serine and the pathways of L-serine utilization in disease and during development, in particular of the central nervous system. |
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Authors:
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Tom J de Koning; Keith Snell; Marinus Duran; Ruud Berger; Bwee-Tien Poll-The; Robert Surtees |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The Biochemical journal Volume: 371 ISSN: 0264-6021 ISO Abbreviation: Biochem. J. Publication Date: 2003 May |
Date Detail:
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Created Date: 2003-04-18 Completed Date: 2003-05-28 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2984726R Medline TA: Biochem J Country: England |
Other Details:
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Languages: eng Pagination: 653-61 Citation Subset: IM |
Affiliation:
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Department of Pediatric Metabolic Diseases, University Medical Centre Utrecht, KC 03.063.0, P.O. Box 85090, 3508 AB Utrecht, The Netherlands. t.dekoning@wkz.azu.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Metabolism, Inborn Errors
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physiopathology* Central Nervous System / physiology Gluconeogenesis / physiology Humans Serine / biosynthesis, chemistry, physiology* |
| Chemical | |
Reg. No./Substance:
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56-45-1/Serine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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