Document Detail


L-nucleoside enantiomers as antivirals drugs: a mini-review.
MedLine Citation:
PMID:  16797735     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The discovery that some nucleoside analogues endowed with the unnatural L-configuration can possess biological activities has been a significant breakthrough in antiviral chemotherapy. In this regard, lamivudine (3TC) was the first L-nucleoside enantiomer approved against HIV and HBV, and several other L-nucleosides are currently under clinical development as antiviral agents.
Authors:
Christophe Mathé; Gilles Gosselin
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Publication Detail:
Type:  Journal Article; Review     Date:  2006-05-23
Journal Detail:
Title:  Antiviral research     Volume:  71     ISSN:  0166-3542     ISO Abbreviation:  Antiviral Res.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-21     Completed Date:  2006-11-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8109699     Medline TA:  Antiviral Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  276-81     Citation Subset:  IM    
Affiliation:
Laboratoire de Chimie Organique Biomoléculaire de Synthèse, UMR 5625 CNRS, Université Montpellier II, Case Courrier 008, Place Eugène Bataillon, 34095 Montpellier, France.
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MeSH Terms
Descriptor/Qualifier:
Antiviral Agents / chemistry*,  pharmacology*
Cytomegalovirus / drug effects
Hepatitis B virus / drug effects
Humans
Nucleosides / chemistry*,  pharmacology*
Stereoisomerism
Virus Diseases / virology
Viruses / drug effects
Chemical
Reg. No./Substance:
0/Antiviral Agents; 0/Nucleosides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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