Document Detail


L-lysine dose dependently delays gastric emptying and increases intestinal fluid volume in humans and rats.
MedLine Citation:
PMID:  24890878     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Novel sensory inputs for the control of food intake and gastrointestinal (GI) function are of increasing interest due to the rapid increase in nutrition-related diseases. The essential amino acid L-lysine was demonstrated to have a selective impact on food intake, gastric emptying, and intestinal transit in rats, thus indicating a potential novel direct sensory input to assess dietary protein content and quality. The aim of this study was to assess translational aspects of this finding and to investigate the dose-dependent effect of L-lysine on human and rat GI function.
METHODS: L-lysine doses from 0-800 mg in rats and 0.5-7.5 g in humans were analyzed for their effect on gastric emptying and GI secretion. Human GI function was assessed non-invasively using magnetic resonance imaging (MRI), rat data were acquired using standard lethal measurement methods. L-lysine dose dependently delayed gastric emptying and stimulated GI secretion in rats as reflected by residual phenol red content and increased gastric wet weight.
KEY RESULTS: The dose-dependent delay in gastric emptying observed in rats was confirmed in humans with an increase in halftime of gastric emptying of 4 min/g L-lysine, p < 0.01. Moreover, a dose-dependent increase in intestinal fluid accumulation was observed (0.4 mL/min/g L-lysine, p < 0.0001). No effect on alkaline tide, glucose concentration, hematocrit, or visceral sensations was detected.
CONCLUSIONS & INFERENCES: This translational study demonstrates comparable dose-dependent effects of intragastric L-lysine on GI function in humans and rats and suggests a broader role for individual amino acids in the control of GI motility and secretion in vivo.
Authors:
C Baruffol; J Jordi; S Camargo; T Radovic; B Herzog; M Fried; W Schwizer; F Verrey; T A Lutz; A Steingoetter
Related Documents :
9514208 - Inhibition of dopamine and choline acetyltransferase concentrations in rat cns neurons ...
2731778 - Antithrombotic effects of three thrombin inhibitors in a rat model of laser-induced thr...
13727138 - Histochemical demonstration in rat of monoamine oxidase inhibition of beta-phenyl-isopr...
8053938 - Propyl gallate as a hepatoprotector in vitro and in vivo.
18262568 - Enforced physical training promotes neurogenesis in the subgranular zone after focal ce...
3389038 - Inhibition of 5 alpha-reductase activity in prepubertal female rats: effect on the timi...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-6-1
Journal Detail:
Title:  Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society     Volume:  -     ISSN:  1365-2982     ISO Abbreviation:  Neurogastroenterol. Motil.     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-6-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9432572     Medline TA:  Neurogastroenterol Motil     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2014 John Wiley & Sons Ltd.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Circadian endocrine rhythms: the hypothalamic-pituitary-adrenal axis and its actions.
Next Document:  A cross-sectional survey of antimicrobial stewardship strategies in UK hospitals.