Document Detail

L-isoform but not S-isoform of myelin associated glycoprotein promotes neurite outgrowth of mouse cerebellar neurons.
MedLine Citation:
PMID:  11578829     Owner:  NLM     Status:  MEDLINE    
Myelin associated glycoprotein (MAG) has growth promoting effect on mouse cerebellar neurons. In the present study, we examined which isoform of MAG has the effect. cDNA for L-MAG and S-MAG was stably transfected into BALB/c 3T3 cells, on which cerebellar neurons were cultured. The neurons were stained with antibody against microtubule-associated protein-2. Neurites of the neurons cultured on cells expressing L-MAG extended significantly further than those cultured on cells expressing S-MAG or on control cells. Therefore, intracellular domain of MAG may have the potential to affect MAG-neurite interaction.
C Shimizu-Okabe; Y Matsuda; H Koito; S Yoshida
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroscience letters     Volume:  311     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-10-01     Completed Date:  2001-12-04     Revised Date:  2006-04-21    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  203-5     Citation Subset:  IM    
Department of Immunology, National Institute of Neuroscience, National Center of Neurology on Psychiatry, 4-1-1 Ogawa-higashi, Kodaira, Tokyo 187-8502, Japan.
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MeSH Terms
Animals, Newborn
Cell Count
Cell Differentiation / drug effects*,  physiology
Cell Size / genetics
Cells, Cultured / cytology,  drug effects,  metabolism
Cerebellum / cytology,  drug effects*,  growth & development
Gene Expression / physiology
Genetic Vectors
Mice, Inbred BALB C
Microtubule-Associated Proteins / metabolism
Myelin-Associated Glycoprotein / genetics,  metabolism*
Neurites / drug effects*,  metabolism,  ultrastructure
Protein Isoforms / genetics,  metabolism
Protein Structure, Tertiary / physiology
Reg. No./Substance:
0/Microtubule-Associated Proteins; 0/Myelin-Associated Glycoprotein; 0/Protein Isoforms

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