Document Detail


L-glutamate decreases glucose utilization by rat cortical astrocytes.
MedLine Citation:
PMID:  12902023     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Microenvironmental changes including elevated levels of L-glutamate, ionic homeostasis, acidification, and oxygen level are associated with brain insults. Their effects on energy metabolism were studied in cultured astrocytes. L-glutamate caused a decrease in lactate accumulation through the activation of transporter in astrocytes in a concentration- and time-dependent manner. Decreases in glucose uptake, lactate synthesis and accumulation as well as increases in mitochondrial activity indicated a switch of the astrocytic metabolism from glycolytic to oxidative. Environmental changes co-operated with L-glutamate to regulate the metabolic strategy, e.g. KCl and oxygen deprivation reversed but acidification exacerbated the L-glutamate-mediated decrease in lactate accumulation. Taken together, during chronic exposure, oxidation of non-glucose substrates such as L-glutamate fuels the active transport of L-glutamate into astrocytes.
Authors:
Su-Lan Liao; Chun-Jung Chen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroscience letters     Volume:  348     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-08-06     Completed Date:  2003-09-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  81-4     Citation Subset:  IM    
Affiliation:
Department of Education and Research, Taichung Veterans General Hospital, No. 160, Section 3, Taichung-Gang Road, Taichung 407, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Astrocytes / drug effects,  metabolism*
Brain Injuries / metabolism*,  physiopathology
Cell Hypoxia / drug effects,  physiology
Cells, Cultured
Cerebral Cortex / drug effects,  metabolism*,  physiopathology
Dose-Response Relationship, Drug
Down-Regulation / drug effects,  physiology*
Energy Metabolism / drug effects,  physiology*
Excitatory Amino Acid Transporter 2 / drug effects,  metabolism
Glucose / metabolism*
Glutamic Acid / metabolism*,  pharmacology
Glycolysis / drug effects,  physiology
Homeostasis / drug effects,  physiology
Hydrogen-Ion Concentration / drug effects
Ions / metabolism
Lactic Acid / metabolism
Mitochondria / drug effects,  metabolism
Oxidative Phosphorylation / drug effects
Oxygen / metabolism
Potassium Chloride / pharmacology
Rats
Rats, Sprague-Dawley
Chemical
Reg. No./Substance:
0/Excitatory Amino Acid Transporter 2; 0/Ions; 50-21-5/Lactic Acid; 50-99-7/Glucose; 56-86-0/Glutamic Acid; 7447-40-7/Potassium Chloride; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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