Document Detail

L-ergothioneine modulates oxidative damage in the kidney and liver of rats in vivo: studies upon the profile of polyunsaturated fatty acids.
MedLine Citation:
PMID:  15030958     Owner:  NLM     Status:  MEDLINE    
BACKGROUND & AIMS: L-ergothioneine is a fungal metabolite exhibiting antioxidant functions in cells. The aim of this study was to assess the effect of oral administration of L-ergothioneine on the oxidative damage in vivo caused by the Fenton reagent ferric-nitrilotriacetate. METHODS: Rats were supplemented with L-ergo prior to the administration of acute dose of ferric-nitrilotriacetate. Kidney and liver levels of L-ergothioneine, glutathione, alpha-tocopherol, polyunsaturated fatty acids and conjugated dienes were assessed. RESULTS: Oral administration of 70 mg L-ergo/kg body weight of rats for 7 days prior to the injection of ferric-nitrilotriacetate protected the fatty acids against oxidation, with notable protections directed to: 20:5 (eicosapentaenoic acid) (23%), 22:6 (docosahexaenoinic acid) (30%), 20:3 n6 (eicosatrienoic acid) (22%), 20:4 (arachidonic acid) (25%), 18:2 linoleic acid (25%) and 18:1 oleic acid (14%) in the kidney. The protection of 20:5, 20:3 n6 and 18:1 in the liver by 32%, 20% and 11%, respectively, were statistically significant. L-ergothioneine significantly reduced kidney and liver levels of conjugated dienes and conserved the concentrations of alpha-tocopherol and glutathione in the kidney and liver in the ferric-nitrilotriacetate/L-ergothioneine treated rats. CONCLUSION: Supplementation with L-ergothioneine not only protects the organs against the lipid peroxidation but conserves the consumption of endogenous glutathione and alpha-tocopherol. However consumption of mushrooms may have better promise as dietary sources of L-ergothioneine to humans.
Monica Deiana; Antonella Rosa; Viviana Casu; Rosaria Piga; M Assunta Dessì; Okezie I Aruoma
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical nutrition (Edinburgh, Scotland)     Volume:  23     ISSN:  0261-5614     ISO Abbreviation:  Clin Nutr     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-03-19     Completed Date:  2004-07-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8309603     Medline TA:  Clin Nutr     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  183-93     Citation Subset:  IM    
Dipartimento di Biologia Sperimentale, Sezione Patologia Sperimentale, Università degli Studi di Cagliari, Cittadella Universitaria SS 554, 09042 Monserrato, Cagliari, Italy.
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MeSH Terms
Antioxidants / pharmacology*
Chromatography, High Pressure Liquid
Ergothioneine / analysis,  pharmacology*
Fatty Acids, Unsaturated / analysis
Ferric Compounds / administration & dosage
Glutathione / analysis
Kidney / chemistry,  drug effects*
Lipids / analysis
Liver / chemistry,  drug effects*
Nitrilotriacetic Acid / administration & dosage,  analogs & derivatives*
Oxidative Stress / drug effects*
Rats, Wistar
alpha-Tocopherol / analysis
Reg. No./Substance:
0/Antioxidants; 0/Fatty Acids, Unsaturated; 0/Ferric Compounds; 0/Lipids; 139-13-9/Nitrilotriacetic Acid; 16448-54-7/ferric nitrilotriacetate; 497-30-3/Ergothioneine; 59-02-9/alpha-Tocopherol; 70-18-8/Glutathione

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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