| Is L-dopa an endogenous neurotransmitter? | |
| | |
MedLine Citation:
|
PMID: 8100096 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Since the 1960s, L-3,4-dihydroxyphenylalanine (L-dopa), a precursor of dopamine, has been thought to occur in the cytoplasm of catecholaminergic neurones. L-Dopa is traditionally believed to be an inert amino acid that exerts actions and effectiveness in Parkinson's disease via its conversion to dopamine by L-aromatic amino acid decarboxylase. In contrast to this generally accepted idea, Yoshimi Misu and Yoshio Goshima propose, in this Viewpoint article, that L-dopa itself is an endogenous neurotransmitter or neuromodulator in the CNS. This hypothesis is mainly based on the findings that L-dopa is released in a transmitter-like manner and that exogenously applied levodopa produces some responses. |
| | |
Authors:
|
Y Misu; Y Goshima |
Related Documents
:
|
7244396 - An attempt to control cerebrospinal fluid acidosis in coma due to head injury. 8791186 - Day-to-day intraindividual reliability and interindividual differences in monoamines ex... 739336 - Catecholamine metabolites in the aqueous of retinoblastoma. 2758226 - Effect of changing extracellular levels of magnesium on spontaneous activity and glutam... 16885266 - Kinetic analysis of bifidobacterial metabolism reveals a minor role for succinic acid i... 563466 - Predisposition to spina bifida: search for a relation to maternal gastric acid secretion. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Trends in pharmacological sciences Volume: 14 ISSN: 0165-6147 ISO Abbreviation: Trends Pharmacol. Sci. Publication Date: 1993 Apr |
Date Detail:
|
Created Date: 1993-07-19 Completed Date: 1993-07-19 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7906158 Medline TA: Trends Pharmacol Sci Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 119-23 Citation Subset: IM |
Affiliation:
|
Department of Pharmacology, Yokohama City University School of Medicine, Kanagawa Prefecture, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Dihydroxyphenylalanine / physiology* Humans Levodopa / metabolism* Neurotransmitter Agents / physiology* Receptors, Cell Surface / metabolism, physiology |
| Chemical | |
Reg. No./Substance:
|
0/Levodopa; 0/Neurotransmitter Agents; 0/Receptors, Cell Surface; 63-84-3/Dihydroxyphenylalanine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Hox genes and pattern formation in the branchial region of the vertebrate head.
Next Document: Identification of carriers of haemophilia by polymerase chain reaction.