Document Detail


Is L-dopa an endogenous neurotransmitter?
MedLine Citation:
PMID:  8100096     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Since the 1960s, L-3,4-dihydroxyphenylalanine (L-dopa), a precursor of dopamine, has been thought to occur in the cytoplasm of catecholaminergic neurones. L-Dopa is traditionally believed to be an inert amino acid that exerts actions and effectiveness in Parkinson's disease via its conversion to dopamine by L-aromatic amino acid decarboxylase. In contrast to this generally accepted idea, Yoshimi Misu and Yoshio Goshima propose, in this Viewpoint article, that L-dopa itself is an endogenous neurotransmitter or neuromodulator in the CNS. This hypothesis is mainly based on the findings that L-dopa is released in a transmitter-like manner and that exogenously applied levodopa produces some responses.
Authors:
Y Misu; Y Goshima
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Trends in pharmacological sciences     Volume:  14     ISSN:  0165-6147     ISO Abbreviation:  Trends Pharmacol. Sci.     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-07-19     Completed Date:  1993-07-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906158     Medline TA:  Trends Pharmacol Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  119-23     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Yokohama City University School of Medicine, Kanagawa Prefecture, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Dihydroxyphenylalanine / physiology*
Humans
Levodopa / metabolism*
Neurotransmitter Agents / physiology*
Receptors, Cell Surface / metabolism,  physiology
Chemical
Reg. No./Substance:
0/Levodopa; 0/Neurotransmitter Agents; 0/Receptors, Cell Surface; 63-84-3/Dihydroxyphenylalanine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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