| L-Dopa effect on frequency-dependent depression of the H-reflex in adult rats with complete spinal cord transection. | |
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MedLine Citation:
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PMID: 20637842 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study investigated whether l-dopa (DOPA), locomotor-like passive exercise (Ex) using a motorized bicycle exercise trainer (MBET), or their combination in adult rats with complete spinal cord transection (Tx) preserves and restores low frequency-dependent depression (FDD) of the H-reflex. Adult Sprague-Dawley rats (n=56) transected at T8-9 had one of five treatments beginning 7 days after transection: Tx (transection only), Tx+Ex, Tx+DOPA, Tx+Ex+DOPA, and control (Ctl, no treatment) groups. After 30 days of treatment, FDD of the H-reflex was tested. Stimulation of the tibial nerve at 0.2, 1, 5, and 10Hz evoked an H-reflex that was recorded from plantar muscles of the hind paw. No significant differences were found at the stimulation rate of 1Hz. However, at 5Hz, FDD of the H-reflex in the Tx+Ex, Tx+DOPA and Ctl groups was significantly different from the Tx group (p<0.01). At 10Hz, all of the treatment groups were significantly different from the Tx group (p<0.01). No significant difference was identified between the Ctl and any of the treatment groups. These results suggest that DOPA significantly preserved and restored FDD after transection as effectively as exercise alone or exercise in combination with DOPA. Thus, there was no additive benefit when DOPA was combined with exercise. |
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Authors:
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Hao Liu; Robert D Skinner; Ahmad Arfaj; Charlotte Yates; Nancy B Reese; Keith Williams; Edgar Garcia-Rill |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-07-15 |
Journal Detail:
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Title: Brain research bulletin Volume: 83 ISSN: 1873-2747 ISO Abbreviation: Brain Res. Bull. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-11 Completed Date: 2011-02-23 Revised Date: 2011-06-08 |
Medline Journal Info:
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Nlm Unique ID: 7605818 Medline TA: Brain Res Bull Country: United States |
Other Details:
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Languages: eng Pagination: 262-5 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Dept. of Physical Therapy, Univ. of Central Arkansas, Conway, AR 72035, United States. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dopamine / metabolism Dopamine Agents / pharmacology* Electric Stimulation Exercise Female H-Reflex* / drug effects, physiology Humans Levodopa / pharmacology* Physical Therapy Modalities Random Allocation Rats Rats, Sprague-Dawley Spinal Cord Injuries / physiopathology* |
| Grant Support | |
ID/Acronym/Agency:
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P20 RR020146/RR/NCRR NIH HHS; R01 NS020246-25/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Dopamine Agents; 0/Levodopa |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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