Document Detail

L-deamino-8-d-arginine vasopressin treatment in pregnancy and neonatal outcome. A report of three cases.
MedLine Citation:
PMID:  3718635     Owner:  NLM     Status:  MEDLINE    
Three women with neurohypophyseal diabetes insipidus, treated for prolonged periods, including pregnancy, with L-deamino-8-d-arginine vasopressin, gave birth in our hospital. Two of the infants had severe congenital heart disease, one of which was associated with trisomy 21. The third baby, born prematurely, presented with mild intrauterine growth retardation; at the age of 21 months, the boy had severe failure to thrive, hypotonia, and motor retardation. These three cases raise doubts as to the safety of diabetes insipidus or its treatment in pregnancy.
N Linder; I Matoth; G Ohel; D Yourish; I Tamir
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of perinatology     Volume:  3     ISSN:  0735-1631     ISO Abbreviation:  Am J Perinatol     Publication Date:  1986 Jul 
Date Detail:
Created Date:  1986-08-04     Completed Date:  1986-08-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  165-7     Citation Subset:  IM    
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MeSH Terms
Abnormalities, Drug-Induced / etiology*
Deamino Arginine Vasopressin / adverse effects*
Diabetes Insipidus / drug therapy*
Infant, Newborn
Pregnancy Complications / drug therapy*
Prenatal Exposure Delayed Effects*
Reg. No./Substance:
16679-58-6/Deamino Arginine Vasopressin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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