Document Detail

L-carnitine supplementation in humans. The effects on physical performance.
MedLine Citation:
PMID:  2180829     Owner:  NLM     Status:  MEDLINE    
The use of supplementary L-carnitine by athletes has become rather widespread over the recent years even in the absence of unequivocal results from human experimental studies that might support this practice. To justify the above procedure, the most commonly purported reasons are that L-carnitine administration could hypothetically: 1. increase lipid turnover in working muscles leading to glycogen saving and, as a consequence, allow longer performances for given heavy work loads; 2. contribute to the homeostasis of free and esterified L-carnitine in plasma and muscle, the allegation being that the levels of one or more of these compounds may decrease in the course of heavy repetitive exercise. A critical survey of the literature on carnitine metabolism in healthy humans at exercise does not appear to be available. The authors are of the opinion that this paper, besides shedding light into some relevant aspects of energy turnover in muscle, could also be of practical use not only for the physiologists but particularly for the Sport Medicine practitioners.
P Cerretelli; C Marconi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  International journal of sports medicine     Volume:  11     ISSN:  0172-4622     ISO Abbreviation:  Int J Sports Med     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-05-03     Completed Date:  1990-05-03     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8008349     Medline TA:  Int J Sports Med     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  1-14     Citation Subset:  IM    
Department of Physiology, School of Medicine, University of Geneva.
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MeSH Terms
Carnitine / metabolism,  pharmacokinetics,  pharmacology*
Energy Metabolism / drug effects
Middle Aged
Muscles / drug effects*,  metabolism
Physical Exertion / drug effects*
Reg. No./Substance:

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