| L-carnitine supplementation decreases the left ventricular mass in patients undergoing hemodialysis. | |
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MedLine Citation:
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PMID: 18503218 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Patients on long-term hemodialysis become deficient in carnitine and are frequently treated with carnitine supplementation to offset their renal anemia, lipid abnormality and cardiac dysfunction. The therapeutic value of carnitine supplementation on left ventricular hypertrophy (LVH) in patients with normal cardiac systolic function remains uncertain. METHODS AND RESULTS: The cardiac morphology and function of 10 patients given 10 mg/kg of L-carnitine orally, immediately after hemodialysis sessions 3 times per week for a 12-month period were compared with 10 untreated control patients. Using echocardiography, left ventricular fractional shortening (LVFS) and left ventricular mass index (LVMI) were measured before and after the study period. As a result, amounts of serum-free carnitine increased from 28.4+/-4.7 to 58.5+/-12.1 micromol/L. The LVMI decreased significantly from 151.8+/-21.2 to 134.0+/-16.0 g/m(2) in treated patients (p<0.01), yet the LVMI in untreated control patients did not change significantly (ie, from 153.3+/-28.2 to 167.1+/-43.1 g/m(2)). However, LVFS values remained unchanged in both groups. Although L-carnitine promoted a 31% reduction in erythropoietin requirements, hematocrit and blood pressure did not change during the study period. CONCLUSIONS: Supplementation with L-carnitine induced regression of LVH in patients on hemodialysis, even for those with normal systolic function. |
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Authors:
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Tai Sakurabayashi; Shigeru Miyazaki; Yasuko Yuasa; Shinji Sakai; Masashi Suzuki; Sachio Takahashi; Yoshihei Hirasawa |
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Publication Detail:
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Type: Controlled Clinical Trial; Journal Article; Multicenter Study |
Journal Detail:
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Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 72 ISSN: 1346-9843 ISO Abbreviation: Circ. J. Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-05-26 Completed Date: 2008-09-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
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Languages: eng Pagination: 926-31 Citation Subset: IM |
Affiliation:
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Kidney Center of Shinraku-en Hospital, 3-1-1 Shindori-minami, Niigata 950-2087, Japan. t-sakura@db3.so-net.ne.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Blood Pressure Body Weight Carnitine / administration & dosage* Echocardiography Female Hematocrit Humans Hypertrophy, Left Ventricular / complications, drug therapy*, ultrasonography Kidney Failure, Chronic / complications*, therapy Male Middle Aged Renal Dialysis* Treatment Outcome Vitamin B Complex / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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12001-76-2/Vitamin B Complex; 541-15-1/Carnitine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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