| Effects of L-carnitine on oxidative stress responses in patients with renal disease. | |
| | |
MedLine Citation:
|
PMID: 20216464 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: Hemodialyzed patients demonstrate elevated oxidative stress and reduced functional status. Exercise induces health benefits, but acute exertion up-regulates oxidative stress responses in patients undergoing hemodialysis. Therefore, the aim of the present study was to examine the effect of L-carnitine supplementation on i) exercise performance and ii) blood redox status both at rest and after exercise. METHODS: Twelve hemodialysis patients received either L-carnitine (20 mg kg(-1) i.v.) or placebo in a double-blind, placebo-controlled, counterbalanced, and crossover design for 8 wk. Participants performed an exercise test to exhaustion before and after supplementation. During the test, V˙O2, respiratory quotient, heart rate, and time to exhaustion were monitored. Blood samples, collected before and after exercise, were analyzed for lactate, malondialdehyde, protein carbonyls, reduced and oxidized glutathione, antioxidant capacity, catalase, and glutathione peroxidase activity. RESULTS: Blood carnitine increased by L-carnitine supplementation proportionately at rest and after exercise. L-carnitine supplementation increased time to fatigue (22%) and decreased postexercise lactate (37%), submaximal heart rate, and respiratory quotient but did not affect V˙O2peak. L-carnitine supplementation increased reduced/oxidized glutathione (2.7-fold at rest, 4-fold postexercise) and glutathione peroxidase activity (4.5% at rest, 10% postexercise) and decreased malondialdehyde (19% at rest and postexercise) and protein carbonyl (27% at rest, 40% postexercise) concentration. CONCLUSIONS: Data suggest that a 2-month L-carnitine supplementation may be effective in attenuating oxidative stress responses, enhancing antioxidant status, and improving performance of patients with end-stage renal disease. |
| | |
Authors:
|
Ioannis G Fatouros; Ioannis Douroudos; Stylianos Panagoutsos; Ploumis Pasadakis; Michalis G Nikolaidis; Athanasios Chatzinikolaou; Apostolos Sovatzidis; Yiannis Michailidis; Athanasios Z Jamurtas; Dimitrios Mandalidis; Kyriakos Taxildaris; Vassilios Vargemezis |
Related Documents
:
|
16614824 - Neurotoxicity of the pentabrominated diphenyl ether mixture, de-71, and hexabromocyclod... 7487074 - Induction of ya1 subunit of rat hepatic glutathione s-transferases by exercise-induced ... 15258364 - Blood fluidity is related to the ability to oxidize lipids at exercise. 22572554 - Community-based exercise program is cost-effective by preventing care and disability in... 3318604 - Vascular actions of airway neuropeptides. 18545194 - Temporal strength changes from resistance exercise and albuterol on unloaded muscle. |
Publication Detail:
|
Type: Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Medicine and science in sports and exercise Volume: 42 ISSN: 1530-0315 ISO Abbreviation: Med Sci Sports Exerc Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-09-27 Completed Date: 2011-01-13 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8005433 Medline TA: Med Sci Sports Exerc Country: United States |
Other Details:
|
Languages: eng Pagination: 1809-18 Citation Subset: IM; S |
Affiliation:
|
Department of Physical Education and Sport Science, Democritus University of Thrace, Komotini, Greece. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antioxidants Carnitine / administration & dosage* Catalase / blood Dietary Supplements* Exercise / physiology Fatigue / drug therapy, physiopathology Glutathione / blood Glutathione Peroxidase / blood Heart Rate / physiology Humans Kidney Failure, Chronic / physiopathology* Lactic Acid / blood Male Malondialdehyde / blood Middle Aged Oxidative Stress / drug effects* Oxygen Consumption / physiology Protein Carbonylation / drug effects Renal Dialysis* Vitamin B Complex / blood, pharmacology |
| Chemical | |
Reg. No./Substance:
|
0/Antioxidants; 12001-76-2/Vitamin B Complex; 50-21-5/Lactic Acid; 541-15-1/Carnitine; 542-78-9/Malondialdehyde; 70-18-8/Glutathione; EC 1.11.1.6/Catalase; EC 1.11.1.9/Glutathione Peroxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Identifying clinically meaningful tools for measuring comfort perception of footwear.
Next Document: Physical activity and food consumption in high- and low-active inbred mouse strains.