Document Detail

L-asparaginyl-tRNA synthetase and L-asparagine synthetase activities of L-asparaginase-sensitive and -resistant forms of the mouse Gardner lymphoma 6C3HED.
MedLine Citation:
PMID:  38936     Owner:  NLM     Status:  MEDLINE    
1. The mouse Gardner lymphoma 6C3HED was grown in ascites fluid in a form sensitive to the action of L-asparaginase (line 1), in another form which was resistant to L-asparaginase (line 2) and in a third form with partial sensitivity to L-asparaginase (line 3). 2. The L-asparaginyl-tRNA synthetase activities of extracts of the tumour cells, cultured both in the mouse and in vitro, were determined. Two of the lines, 1 and 3, in early passage numbers, showed a derepression mechanism involving L-asparagine. Mutation occurred with these lines resulting in the L-asparaginyl-tRNA synthetase activity of all the tumour cell lines being the same. 3. Cells of line 1 had low L-asparagine synthetase activity, which was unchanged by altering the supply of L-asparagine in vitro. Cells of lines 2 and 3 exhibited L-asparagine synthetase activities, which changed with the supply of L-asparagine. 4. It is not certain that L-asparagine synthetase activity of L-asparaginase-sensitive cells is controlled by L-asparaginyl-tRNA acting as a corepressor.
M R Davies; L P Lambert; R D Marshall
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  56     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  1979 Jan 
Date Detail:
Created Date:  1979-11-29     Completed Date:  1979-11-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  539-45     Citation Subset:  IM    
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MeSH Terms
Amino Acyl-tRNA Synthetases / metabolism*
Antineoplastic Agents
Ascitic Fluid / metabolism
Asparaginase / metabolism*
Asparagine / biosynthesis
Aspartate-Ammonia Ligase / metabolism*
Cell Transformation, Neoplastic
Cells, Cultured
Ligases / metabolism*
Lymphoma / enzymology*
Mice, Inbred C3H
Neoplasms, Experimental / enzymology*
Time Factors
Reg. No./Substance:
0/Antineoplastic Agents; 7006-34-0/Asparagine; EC; EC 6.-/Ligases; EC 6.1.1.-/Amino Acyl-tRNA Synthetases; EC Ligase

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