| L-asparaginyl-tRNA synthetase and L-asparagine synthetase activities of L-asparaginase-sensitive and -resistant forms of the mouse Gardner lymphoma 6C3HED. | |
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MedLine Citation:
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PMID: 38936 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. The mouse Gardner lymphoma 6C3HED was grown in ascites fluid in a form sensitive to the action of L-asparaginase (line 1), in another form which was resistant to L-asparaginase (line 2) and in a third form with partial sensitivity to L-asparaginase (line 3). 2. The L-asparaginyl-tRNA synthetase activities of extracts of the tumour cells, cultured both in the mouse and in vitro, were determined. Two of the lines, 1 and 3, in early passage numbers, showed a derepression mechanism involving L-asparagine. Mutation occurred with these lines resulting in the L-asparaginyl-tRNA synthetase activity of all the tumour cell lines being the same. 3. Cells of line 1 had low L-asparagine synthetase activity, which was unchanged by altering the supply of L-asparagine in vitro. Cells of lines 2 and 3 exhibited L-asparagine synthetase activities, which changed with the supply of L-asparagine. 4. It is not certain that L-asparagine synthetase activity of L-asparaginase-sensitive cells is controlled by L-asparaginyl-tRNA acting as a corepressor. |
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Authors:
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M R Davies; L P Lambert; R D Marshall |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical science (London, England : 1979) Volume: 56 ISSN: 0143-5221 ISO Abbreviation: Clin. Sci. Publication Date: 1979 Jan |
Date Detail:
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Created Date: 1979-11-29 Completed Date: 1979-11-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7905731 Medline TA: Clin Sci (Lond) Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 539-45 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acyl-tRNA Synthetases
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metabolism* Animals Antineoplastic Agents Ascitic Fluid / metabolism Asparaginase / metabolism* Asparagine / biosynthesis Aspartate-Ammonia Ligase / metabolism* Cell Transformation, Neoplastic Cells, Cultured Horses Ligases / metabolism* Lymphoma / enzymology* Mice Mice, Inbred C3H Neoplasms, Experimental / enzymology* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 7006-34-0/Asparagine; EC 3.5.1.1/Asparaginase; EC 6.-/Ligases; EC 6.1.1.-/Amino Acyl-tRNA Synthetases; EC 6.3.1.1/Aspartate-Ammonia Ligase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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