| L-arginine supplemented nondiluted blood cardioplegia: a clinical trial. | |
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MedLine Citation:
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PMID: 20354500 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: L-arginine was shown to improve protection of the myocardium during coronary artery bypass graft (CABG) surgery. The objective of the present study was to determine the concentration of L-arginine to obtain the most effective protection of the myocardium during CABG surgery. METHODS: Seventy-five patients undergoing CABG surgery were randomized in 3 groups. The first group (N.=25) was administered a placebo injection in the blood cardioplegic solution, the second group (N.=25) received an injection of 4 mmol/L of L-arginine and a third group (N.=25) an injection of 6 mmol/L of L-arginine in the blood cardioplegic solution. Blood samples from the ascending aorta and the coronary sinus catheter were collected before, immediately after and at 20 minutes after aortic cross-clamping. Total plasmatic nitrite and nitrate ratio and lactate release from the myocardium in the collected blood samples were measured. RESULTS: Seventy-five patients averaging 62+/-7 years of age and undergoing 3.1+/-1 coronary bypass grafts during 41+/-17 minutes of aortic cross clamping time were recruited. Values of total plasmatic nitrite and nitrate ratio remains non-significant before and after aortic clamping and also between groups (P=0.9812 and 0.3573 respectively). Myocardial lactate release was statistically different before and after cross clamping (P=0.0002) and also between the 3 groups (P=0.0311). CONCLUSION: Nondiluted blood cardioplegic solution supplemented with 4 mmol/L of L-arginine was associated with a significant decrease of myocardial lactate release after aortic cross-clamping and reperfusion during CABG surgery. |
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Authors:
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M Carrier; L P Perrault; A Fortier; D Bouchard; M Pellerin |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: The Journal of cardiovascular surgery Volume: 51 ISSN: 0021-9509 ISO Abbreviation: J Cardiovasc Surg (Torino) Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-31 Completed Date: 2010-07-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0066127 Medline TA: J Cardiovasc Surg (Torino) Country: Italy |
Other Details:
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Languages: eng Pagination: 283-7 Citation Subset: IM |
Affiliation:
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Department of Cardiac Surgery, Montreal Heart Institute and Université de Montréal, Montreal, QC, Canada. michel.carrier@icm-mhi.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Arginine / administration & dosage* Biological Markers / blood Cardioplegic Solutions / administration & dosage* Chi-Square Distribution Coronary Artery Bypass* / adverse effects Dose-Response Relationship, Drug Female Heart Arrest, Induced / methods* Heart Diseases / blood, etiology, prevention & control* Humans Lactic Acid / blood Male Middle Aged Nitrates / blood Nitrites / blood Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Cardioplegic Solutions; 0/Nitrates; 0/Nitrites; 50-21-5/Lactic Acid; 74-79-3/Arginine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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