Document Detail

L-arginine reduces exercise-induced increase in plasma lactate and ammonia.
MedLine Citation:
PMID:  12215958     Owner:  NLM     Status:  MEDLINE    
To investigate the effect of L-arginine supplementation (L-ARG) on physiological and metabolic changes during exercise, we determined in a double-blind study the cardiorespiratory (heart rate, oxygen consumption (VO(2)) and carbon dioxide production (VCO(2)) and the metabolic (lactate and ammonia) responses to maximal exercise after either an intravenous L-ARG hydrochloride salt or placebo load in 8 healthy subjects. Exercise-induced increases in heart rate, VO(2) and VCO(2) were not significantly different after L-ARG or placebo. By contrast, peak plasma ammonia and lactate were significantly decreased after L-ARG load (60.6 +/- 8.2 vs. 73.1 +/- 9.1 micro mol x l(-1), p < 0.01 and 7.1 +/- 0.7 vs. 8.2 +/- 1.1 mmol x l(-1), p < 0.01, for ammonia and lactate, respectively). Plasma L-citrulline increased significantly during exercise only after L-ARG load, despite a concomitant decrease in plasma L-ARG. Furthermore, a significant inverse relationship was observed between changes in lactate and L-citrulline concentrations after L-ARG load (r = -0.84, p = 0.009). These results demonstrate that intravenous L-ARG reduces significantly exercise-induced increase in plasma lactate and ammonia. Taken together, the specific L-citrulline increase and the inverse relationship observed between L-citrulline and plasma lactate after L-ARG might support that L-ARG supplementation enhances the L-arginine-nitric oxide (NO) pathway during exercise.
A Schaefer; F Piquard; B Geny; S Doutreleau; E Lampert; B Mettauer; J Lonsdorfer
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  International journal of sports medicine     Volume:  23     ISSN:  0172-4622     ISO Abbreviation:  Int J Sports Med     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-09-06     Completed Date:  2003-02-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8008349     Medline TA:  Int J Sports Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  403-7     Citation Subset:  IM    
Service des Explorations Fonctionnelles Respiratoires et de l'Exercice et EA 3072, Hôpitaux Universitaires et Faculté de Médecine, Strasbourg, France.
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MeSH Terms
Ammonia / blood*
Arginine / blood,  pharmacology*
Citrulline / blood
Double-Blind Method
Exercise / physiology*
Lactates / blood*
Muscle, Skeletal / metabolism
Nitric Oxide / metabolism
Ornithine / blood
Reg. No./Substance:
0/Lactates; 10102-43-9/Nitric Oxide; 372-75-8/Citrulline; 7006-33-9/Ornithine; 74-79-3/Arginine; 7664-41-7/Ammonia

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