| L-arginine reduces exercise-induced increase in plasma lactate and ammonia. | |
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MedLine Citation:
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PMID: 12215958 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To investigate the effect of L-arginine supplementation (L-ARG) on physiological and metabolic changes during exercise, we determined in a double-blind study the cardiorespiratory (heart rate, oxygen consumption (VO(2)) and carbon dioxide production (VCO(2)) and the metabolic (lactate and ammonia) responses to maximal exercise after either an intravenous L-ARG hydrochloride salt or placebo load in 8 healthy subjects. Exercise-induced increases in heart rate, VO(2) and VCO(2) were not significantly different after L-ARG or placebo. By contrast, peak plasma ammonia and lactate were significantly decreased after L-ARG load (60.6 +/- 8.2 vs. 73.1 +/- 9.1 micro mol x l(-1), p < 0.01 and 7.1 +/- 0.7 vs. 8.2 +/- 1.1 mmol x l(-1), p < 0.01, for ammonia and lactate, respectively). Plasma L-citrulline increased significantly during exercise only after L-ARG load, despite a concomitant decrease in plasma L-ARG. Furthermore, a significant inverse relationship was observed between changes in lactate and L-citrulline concentrations after L-ARG load (r = -0.84, p = 0.009). These results demonstrate that intravenous L-ARG reduces significantly exercise-induced increase in plasma lactate and ammonia. Taken together, the specific L-citrulline increase and the inverse relationship observed between L-citrulline and plasma lactate after L-ARG might support that L-ARG supplementation enhances the L-arginine-nitric oxide (NO) pathway during exercise. |
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Authors:
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A Schaefer; F Piquard; B Geny; S Doutreleau; E Lampert; B Mettauer; J Lonsdorfer |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: International journal of sports medicine Volume: 23 ISSN: 0172-4622 ISO Abbreviation: Int J Sports Med Publication Date: 2002 Aug |
Date Detail:
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Created Date: 2002-09-06 Completed Date: 2003-02-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8008349 Medline TA: Int J Sports Med Country: Germany |
Other Details:
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Languages: eng Pagination: 403-7 Citation Subset: IM |
Affiliation:
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Service des Explorations Fonctionnelles Respiratoires et de l'Exercice et EA 3072, Hôpitaux Universitaires et Faculté de Médecine, Strasbourg, France. Adrien.Schaefer@physio-ulp.u-strasbg.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Ammonia / blood* Arginine / blood, pharmacology* Citrulline / blood Double-Blind Method Exercise / physiology* Humans Lactates / blood* Male Muscle, Skeletal / metabolism Nitric Oxide / metabolism Ornithine / blood |
| Chemical | |
Reg. No./Substance:
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0/Lactates; 10102-43-9/Nitric Oxide; 372-75-8/Citrulline; 7006-33-9/Ornithine; 74-79-3/Arginine; 7664-41-7/Ammonia |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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