| L-arginine and pancreatic islet blood flow in anesthetized rats. | |
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MedLine Citation:
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PMID: 8631393 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the present study was to see if L-arginine, which induces insulin release and is a precursor of the endothelial-derived relaxing factor nitric oxide, affects whole pancreatic and/or islet blood flow. For this purpose, anesthetized male Sprague-Dawley rats were injected intravenously with either saline or L-arginine (25, 100 or 250 mg/kg body weight). All doses of arginine caused a slight increase in blood glucose concentration, while the highest dose (250 mg/kg body weight) also increased insulin concentration. However, no changes in either mean arterial blood pressure, whole pancreatic or islet blood flow could be discerned with any of the doses of arginine used. It is concluded that insulin release is not necessarily associated with an increased islet blood perfusion. |
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Authors:
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A M Svensson; L Jansson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Experientia Volume: 52 ISSN: 0014-4754 ISO Abbreviation: Experientia Publication Date: 1996 Mar |
Date Detail:
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Created Date: 1996-07-03 Completed Date: 1996-07-03 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0376547 Medline TA: Experientia Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 239-41 Citation Subset: IM |
Affiliation:
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Department of Medical Cell Biology, Uppsala University, Biomedical Center, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arginine / physiology* Blood Glucose / metabolism Insulin / blood Islets of Langerhans / blood supply* Male Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 11061-68-0/Insulin; 74-79-3/Arginine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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