| L-arginine attenuates ketamine-induced increase in renal sympathetic nerve activity. | |
| | |
MedLine Citation:
|
PMID: 8042783 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: It has been reported that ketamine produces sympathoexcitation by directly stimulating the central nervous system. It also has been shown that nitric oxide (NO) may play a role in signal transduction of the nervous system. Therefore, we hypothesized that the sympathoexcitation of ketamine may be linked to central NO formation. To test this hypothesis, we examined the effects of L-arginine, a substrate of NO formation, on renal sympathetic nerve activity (RSNA) during ketamine anesthesia. METHODS: Using 45 rabbits given basal anesthesia with alpha-chloralose, we measured changes in heart rate, mean arterial pressure, and RSNA in response to intravenous ketamine (1 mg/kg) and investigated the effect of intravenous L-arginine and D-arginine (bolus 30 mg/kg followed by continuous 30 mg.kg-1.min-1). The animals were divided into intact, sinoaortic- and vagal-deafferented, and spinal cord-transected groups. RESULTS: Ketamine caused significant increases in RSNA (172 +/- 16%), heart rate (12 +/- 2 beats/min), and mean arterial pressure (8 +/- 1 mmHg) in the intact rabbits. Ketamine also increased RSNA in sinoaortic- and vagal-deafferented rabbits, but not in spinal cord-transected rabbits. L-Arginine attenuated the ketamine-induced increase in RSNA in intact and deafferented rabbits, whereas D-arginine had no effect on RSNA. In addition, NG-nitro-L-arginine methyl ester, a NO synthase inhibitor, increased RSNA and the increase was attenuated by L-arginine. CONCLUSIONS: Ketamine may act centrally to increase sympathetic outflow, and the sympathoexcitation may be attenuated by increasing NO formation with L-arginine in the central nervous system. |
| | |
Authors:
|
H Okamoto; S Hoka; T Kawasaki; T Okuyama; S Takahashi |
Related Documents
:
|
7711463 - Oral l-arginine supplementation has no effect on cardiovascular responses to lower body... 12234113 - Inhibition of beta-1 receptor but not vagotomy can abolish the l-name evoked bradycardi... 18277323 - Incorporating self-blood pressure measurements at home in the guideline from the ohasam... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Anesthesiology Volume: 81 ISSN: 0003-3022 ISO Abbreviation: Anesthesiology Publication Date: 1994 Jul |
Date Detail:
|
Created Date: 1994-08-25 Completed Date: 1994-08-25 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 1300217 Medline TA: Anesthesiology Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 137-46 Citation Subset: AIM; IM |
Affiliation:
|
Department of Anesthesiology and Critical Care Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Arginine / analogs & derivatives, pharmacology* Blood Pressure / drug effects Drug Interactions Heart Rate / drug effects Ketamine / antagonists & inhibitors*, pharmacology* Kidney / drug effects*, innervation* NG-Nitroarginine Methyl Ester Rabbits Spinal Cord / physiology, surgery Stereoisomerism Sympathetic Nervous System / drug effects* |
| Chemical | |
Reg. No./Substance:
|
50903-99-6/NG-Nitroarginine Methyl Ester; 6740-88-1/Ketamine; 74-79-3/Arginine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Hearing acuity of anesthesiologists and alarm detection.
Next Document: Effects of halothane and propofol on purified brain protein kinase C activation.