Document Detail

L-Arginine as a potential ergogenic aid in healthy subjects.
MedLine Citation:
PMID:  21395365     Owner:  NLM     Status:  MEDLINE    
Dietary supplements containing L-arginine, a semi-essential amino acid, are one of the latest ergogenic aids intended to enhance strength, power and muscle recovery associated with both aerobic and resistance exercise. L-arginine is claimed to promote vasodilation by increasing nitric oxide (NO) production in the active muscle during exercise, improving strength, power and muscular recovery through increased substrate utilization and metabolite removal, such as lactate and ammonia. Research on L-arginine has recently tested this hypothesis, under the assumption that it may be the active compound associated with the vasodilator effects of NO. There were only five acute studies retrieved from the literature that evaluated exercise performance after L-arginine supplementation, three of which reported significant improvements. Regarding studies on chronic effects, eight studies were encountered: four reported enhancements in exercise performance, whilst four reports showed no changes. Whether these improvements in exercise performance - regardless of the aerobic or anaerobic nature of the exercise - can be associated with increases in NO production, has yet to be demonstrated in future studies. Low oral doses (≤20 g) are well tolerated and clinical side effects are rare in healthy subjects. In summary, it is still premature to recommend dietary supplements containing L-arginine as an ergogenic aid for healthy physically active subjects.
Thiago S Álvares; Cláudia M Meirelles; Yagesh N Bhambhani; Vânia M F Paschoalin; Paulo S C Gomes
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Sports medicine (Auckland, N.Z.)     Volume:  41     ISSN:  1179-2035     ISO Abbreviation:  Sports Med     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-14     Completed Date:  2011-07-15     Revised Date:  2013-05-16    
Medline Journal Info:
Nlm Unique ID:  8412297     Medline TA:  Sports Med     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  233-48     Citation Subset:  IM    
Copyright Information:
© 2011 Adis Data Information BV. All rights reserved.
Laboratory Crossbridges, Center for Interdisciplinary Research in Health, Department of Physical Education, Universidade Gama Filho, Rio de Janeiro, Brazil.
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MeSH Terms
Arginine / adverse effects,  pharmacology*
Athletic Performance / physiology*
Dietary Supplements*
Energy Metabolism / drug effects*
Exercise / physiology
Muscle Strength / drug effects*
Nitric Oxide / metabolism
Physical Endurance / drug effects*
Physical Fitness / physiology
Resistance Training
Vasodilation / physiology
Reg. No./Substance:
10102-43-9/Nitric Oxide; 74-79-3/Arginine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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