| L-arginine and antineutrophil serum enable venular control of capillary perfusion in hypercholesterolemic rats. | |
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MedLine Citation:
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PMID: 12483545 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of this study was to investigate and counteract dysfunctional control of capillary flow in hypercholesterolemia. Capillary flow is controlled by arteriolar tone, which in turn is influenced by mediators released from closely paired venules in a mechanism that involves nitric oxide (NO). However, venular control of capillary flow is altered with hypercholesterolemia. METHODS: Rats were given a normal or high-cholesterol diet before measurements of mesenteric capillary red blood cell velocity. The arteriolar pathway leading to the capillary was videotaped to measure the percent of the surrounding area (within 15 |gmm) that was occupied by a venule (% pairing). RESULTS: Venule-paired arterioles were significantly smaller in hypercholesterolemia compared with normocholesterolemia, corresponding to slower capillary flow. A positive correlation between capillary velocity and % pairing observed in normocholesterolemia was not observed during NO synthase inhibition or in hypercholesterolemic rats. However, positive correlations between the two parameters were found in hypercholesterolemia when the rats were given drinking water supplementation of L-arginine or an injection of antineutrophil serum, both of which tended to improve velocity in capillaries branching from venule-paired arteriolar pathways. CONCLUSIONS: Dysfunctional venular control of capillary perfusion in hypercholesterolemia may be a consequence of a neutrophil-mediated deficiency of NO. |
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Authors:
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Kavitha Nellore; Norman R Harris |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Microcirculation (New York, N.Y. : 1994) Volume: 9 ISSN: 1073-9688 ISO Abbreviation: Microcirculation Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2002-12-16 Completed Date: 2003-11-20 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9434935 Medline TA: Microcirculation Country: United States |
Other Details:
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Languages: eng Pagination: 477-85 Citation Subset: IM |
Affiliation:
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Bioengineering Department, Pennsylvania State University, University Park, PA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies, Antineutrophil Cytoplasmic / pharmacology* Arginine / pharmacology* Capillaries / drug effects, physiology* Hypercholesterolemia / drug therapy*, physiopathology* Immune Sera / pharmacology Leukocytes / immunology, physiology Male Microscopy, Video Nitric Oxide / pharmacology Perfusion Rats Rats, Wistar Venules / drug effects*, physiology |
| Grant Support | |
ID/Acronym/Agency:
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HL-55255/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Antineutrophil Cytoplasmic; 0/Immune Sera; 10102-43-9/Nitric Oxide; 74-79-3/Arginine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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