| L-alpha-phosphatidylcholine-induced stimulation of PGI2 production in canine gallbladders following hypovolemic shock and Escherichia coli sepsis. | |
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MedLine Citation:
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PMID: 1920504 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In vitro production of PGI2 in canine gallbladders subjected to hypovolemic shock and Escherichia coli sepsis was studied to determine whether a precursor above arachidonic acid in the cyclooxyenase cascade might be operative in the production of prostacyclin, which, in turn, may play a role in the pathogenesis of acute acalculous cholecystitis (AC). L-alpha-phosphatidylcholine (LaP), an arachidonic acid precursor, was used as the test agent. LaP did not stimulate PGI2 production from either gallbladder surface in the hypovelimic animals or the mucosa of the septic shock group. However, it did stimulate PGI2 production from the SS serosa compared with controls, 1375 +/- 432 versus 633 +/- 198 pg/cm2/min (P less than .05). In conclusion, lack of stimulation of PGI2 in the hypovolemic model suggests that PGI2 does not play a role in AC. Alternatively, it may play a role in preventing this disease process in septic shock. This study demonstrates the use of precursors of arachidonic acid and the cyclooxygenase pathway as active participants in the production of PGI2, although it is unclear whether the prostacyclin produced helps prevent AC in septic shock. |
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Authors:
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E L Hoover; B S Harrison; W L Williams; C Z Adams; W L Weaver |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of the National Medical Association Volume: 83 ISSN: 0027-9684 ISO Abbreviation: J Natl Med Assoc Publication Date: 1991 Apr |
Date Detail:
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Created Date: 1991-11-20 Completed Date: 1991-11-20 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7503090 Medline TA: J Natl Med Assoc Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 325-8 Citation Subset: IM |
Affiliation:
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Department of Surgery, Meharry Medical College, Nashville, Tennessee. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Animals Cholecystitis / etiology* Dogs Epoprostenol / analysis, biosynthesis* Escherichia coli Infections / complications, physiopathology* Female Gallbladder / chemistry, drug effects, metabolism* Phosphatidylcholines / pharmacology Shock / complications, physiopathology* Shock, Septic / complications, physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Phosphatidylcholines; 35121-78-9/Epoprostenol |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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