Document Detail

L-alanyl-glutamine pretreatment attenuates acute inflammatory response in children submitted to palatoplasty.
MedLine Citation:
PMID:  21971662     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate the effects of L-alanyl-glutamine (L-Ala-Gln) pretreatment on oxidative stress, glycemic control and inflammatory response in children submitted to palatoplasty.
METHODS: Thirty male children scheduled for routine palatoplasty, age range 2-10 years, were randomly assigned to 2 groups (n=15): Group A (saline, control) and Group B (L-Ala-Gln). Group A received normal saline 100 ml, delivered intravenously by infusion pump over 3 hours preceding surgical procedure. Group B was treated with L-Ala-Gln, 20% solution (0.5g/Kg), adding saline to complete 100ml. Peripheral venous blood samples were collected at 5 different time-points: T1- at the beginning of the study, 3 h prior to the surgical procedure; T2- at the end of the infusion (before the surgical procedure), T3- at the end of the surgical procedure, T4- 6 h postoperative and T5- 12 h postoperative. Parameters analyzed included glutathione (GSH), thiobarbituric acid reactive substances (TBARS), glucose, insulin, C-reactive protein (CRP) and interleukin-6 (IL-6).
RESULTS: No statistically significant differences were found between groups comparing glucose, insulin, TBARS, GSH and IL-6 levels. However, glucose levels increased (P <0.001) in T4 and T5 as compared to baseline (T1) in control group as opposed to L-Ala-Gln group. IL-6 increased in both groups during the postoperative period, indicating an increased inflammatory response. L-Ala-Gln pretreatment did not suppress the increase of IL-6, but reduced the increase of postoperative CRP levels (T5, p <0.01).
CONCLUSION: Pretreatment with L-Ala-Gln in children submitted to palatoplasty attenuates the inflammatory response in early post-operative period and promoted a better glycemic control.
José Ferreira da Cunha Filho; Isabelle Ivo Gonçalves; Sergio Botelho Guimarães; Francisco Vagnaldo Fechine Jamacaru; José Huygens Parente Garcia; Paulo Roberto Leitão de Vasconcelos
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Acta cirúrgica brasileira / Sociedade Brasileira para Desenvolvimento Pesquisa em Cirurgia     Volume:  26 Suppl 1     ISSN:  1678-2674     ISO Abbreviation:  Acta Cir Bras     Publication Date:  2011  
Date Detail:
Created Date:  2011-10-05     Completed Date:  2012-06-22     Revised Date:  2013-05-27    
Medline Journal Info:
Nlm Unique ID:  9103983     Medline TA:  Acta Cir Bras     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  72-6     Citation Subset:  IM    
Federal University of Ceara, Fortaleza-CE, Brazil.
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MeSH Terms
Analysis of Variance
Blood Glucose / drug effects
C-Reactive Protein / analysis
Case-Control Studies
Child, Preschool
Cleft Lip / metabolism,  surgery*
Cleft Palate / metabolism,  surgery*
Dipeptides / pharmacology*
Glutathione / blood
Inflammation / metabolism,  prevention & control
Interleukin-6 / blood
Oxidative Stress / drug effects
Postoperative Period
Prospective Studies
Single-Blind Method
Statistics, Nonparametric
Surgical Wound Infection / drug therapy*,  prevention & control
Thiobarbituric Acid Reactive Substances / analysis
Time Factors
Reg. No./Substance:
0/Blood Glucose; 0/Dipeptides; 0/Interleukin-6; 0/Thiobarbituric Acid Reactive Substances; 70-18-8/Glutathione; 9007-41-4/C-Reactive Protein; U5JDO2770Z/alanylglutamine

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