| L-Proline transport by isolated renal tubules from newborn and adult rats. | |
| | |
MedLine Citation:
|
PMID: 6835714 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Proline uptake and metabolism has been examined in newborn Sprague-Dawley rat kidney and compared to that in adult animals. [14C]-Proline uptake by renal tubule fragments from newborn rats occurs at the same initial rate as in adult tubules, but at physiologic concentrations achieves significantly higher intracellular levels after 15 min of incubation. Considerable metabolism of the proline taken up was observed in tissue of both ages. Analysis of acid soluble and insoluble tubule fractions from newborn and adults indicates similar degrees of proline incorporation into protein and oxidation to CO2 relative to the amount of radioactivity taken up. A major difference exists, however, with respect to the labeled components of the acid extract: adult tubules convert [14C]-proline to metabolites at a rate twice that of newborn. Analysis of concentration-dependent uptake data reveals two distinct entry systems for proline in both isolated newborn and adult tubules. No difference in the Km or Vmax was found between the young and mature tubules. |
| | |
Authors:
|
S M Hwang; M A Serabian; K S Roth; S Segal |
Related Documents
:
|
4155974 - The action of indoramin and other compounds on the uptake of neurotransmitters into rat... 6192784 - Vascular structural changes in the artery wall of unilateral nephrectomized rats. 16631124 - Inhibitory effects of cis- and trans-resveratrol on noradrenaline and 5-hydroxytryptami... 7851504 - Facilitatory effects of somatostatin on reduced uptake of 2-deoxyglucose in cerebral co... 7635424 - Synaptosomal glutamate transport in thioacetamide-induced hepatic encephalopathy in the... 7310534 - Vitamin k-dependent reactions in rat liver: role of flavoproteins. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Pediatric research Volume: 17 ISSN: 0031-3998 ISO Abbreviation: Pediatr. Res. Publication Date: 1983 Jan |
Date Detail:
|
Created Date: 1983-05-05 Completed Date: 1983-05-05 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 42-6 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Age Factors Animals Animals, Newborn Female Kidney Cortex / metabolism Kidney Tubules / analysis, metabolism* Male Proline / blood, metabolism*, urine Rats Rats, Inbred Strains Time Factors |
| Grant Support | |
ID/Acronym/Agency:
|
AM 10894/AM/NIADDK NIH HHS; HD 08536/HD/NICHD NIH HHS; K04 HD00257/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
|
147-85-3/Proline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Sleep respiratory instability in term neonates under hyperthermic conditions: age, sex, type of feed...
Next Document: Influence of exogenous glucagon on fetal glucose metabolism and ketone production.