Document Detail

L and H cells of nodular lymphocyte predominant Hodgkin's disease show immunoglobulin light-chain restriction.
MedLine Citation:
PMID:  1721489     Owner:  NLM     Status:  MEDLINE    
The nodular form of lymphocyte predominant Hodgkin's disease (NLPHD) is widely accepted to be a B-cell-derived neoplasm. Despite this consensus, previous studies have not shown monotypic immunoglobulin (Ig) light-chain expression by the putatively malignant L & H cells. We have studied paraffin-embedded tissue from 19 cases of NLPHD for the presence of Ig light and heavy chains and J chain. In addition, frozen tissue, available from one case, was examined with antibodies to light chains. In paraffin material, in each case L & H cells in individual nodules were examined for the presence of Ig light chain restriction. Kappa-light-chain restriction was detected in all L & H cells in all nodules in 5/19 cases (26.5%) and this was confirmed in frozen sections available from one case. Of the remaining 14 cases, 13 (68.5%) showed kappa-light-chain restriction in a proportion of nodules and in 1 case light-chain restriction was not observed. Of 14 cases stained with antibodies to Ig heavy chains 13 contained IgG, and in 1 case no heavy chains were demonstrable. Most L & H cells in 15 cases examined contained J chain. Our finding of monotypic L & H cells in NLPHD in 95% of our investigated cases provides strong evidence for the neoplastic nature of L & H cells and supports the hypothesis that NLPHD is a malignant nonHodgkin's B-cell lymphoma.
C Schmid; C Sargent; P G Isaacson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of pathology     Volume:  139     ISSN:  0002-9440     ISO Abbreviation:  Am. J. Pathol.     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-01-22     Completed Date:  1992-01-22     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370502     Medline TA:  Am J Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1281-9     Citation Subset:  AIM; IM    
Department of Histopathology, University College and Middlesex School of Medicine, London, United Kingdom.
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MeSH Terms
Antigens, CD / analysis
Hodgkin Disease / classification,  metabolism,  pathology*
Immunoglobulin G / metabolism
Immunoglobulin J-Chains / metabolism
Immunoglobulin Light Chains / metabolism*
Immunohistochemistry / methods
Lymphocytes / pathology*
Staining and Labeling
Reg. No./Substance:
0/Antigens, CD; 0/Immunoglobulin G; 0/Immunoglobulin J-Chains; 0/Immunoglobulin Light Chains

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