Document Detail

L-DOPA is converted to dopamine in serotonergic fibers of the striatum of the rat: a double-labeling immunofluorescence study.
MedLine Citation:
PMID:  8584208     Owner:  NLM     Status:  MEDLINE    
The aim of the present study is to examine whether serotonergic terminals of the rat brain are induced to contain dopamine by L-DOPA administration. In rats that received intraperitoneally L-DOPA plus a peripheral decarboxylase inhibitor, we showed by use of a double-labeling immunofluorescence method that dopamine was localized in serotonergic fibers of the striatum and cerebral cortex as well as in serotonergic cell bodies of the midbrain raphe nuclei. In normal rats, no dopamine was detected in the serotonergic fibers or cell bodies. The finding suggests that a part of the administered L-DOPA may enter the serotonergic terminals and be converted to dopamine in the rat brain.
R Arai; N Karasawa; M Geffard; I Nagatsu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroscience letters     Volume:  195     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1996-03-21     Completed Date:  1996-03-21     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  195-8     Citation Subset:  IM    
Department of Anatomy, Fujita Health University School of Medicine, Aichi, Japan.
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MeSH Terms
Cerebral Cortex / metabolism
Dopamine / metabolism*
Fluorescent Antibody Technique
Levodopa / metabolism*
Neostriatum / cytology*,  metabolism
Nerve Fibers / metabolism*
Raphe Nuclei / metabolism
Rats, Sprague-Dawley
Serotonin / physiology*
Reg. No./Substance:
0/Levodopa; 50-67-9/Serotonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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