Document Detail


L-DOPA is converted to dopamine in serotonergic fibers of the striatum of the rat: a double-labeling immunofluorescence study.
MedLine Citation:
PMID:  8584208     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the present study is to examine whether serotonergic terminals of the rat brain are induced to contain dopamine by L-DOPA administration. In rats that received intraperitoneally L-DOPA plus a peripheral decarboxylase inhibitor, we showed by use of a double-labeling immunofluorescence method that dopamine was localized in serotonergic fibers of the striatum and cerebral cortex as well as in serotonergic cell bodies of the midbrain raphe nuclei. In normal rats, no dopamine was detected in the serotonergic fibers or cell bodies. The finding suggests that a part of the administered L-DOPA may enter the serotonergic terminals and be converted to dopamine in the rat brain.
Authors:
R Arai; N Karasawa; M Geffard; I Nagatsu
Related Documents :
1306808 - Developmental aspects of the monoamine-degrading enzyme monoamine oxidase.
13620848 - The respiration and cytochrome oxidase activity of rat aorta in experimental hypertension.
24101388 - Influence of fundectomy and intraperitoneal or intragastric administration of apelin on...
1980888 - Isoelectric analysis of 3h-pargyline-labelled monoamine oxidase in rat and carp.
1842558 - Effects of bovine, human and rat growth hormones on immature hypophysectomized rat testis.
6394488 - Chronic arterial and venous catheterization of conscious, unrestrained rats.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroscience letters     Volume:  195     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1996-03-21     Completed Date:  1996-03-21     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  195-8     Citation Subset:  IM    
Affiliation:
Department of Anatomy, Fujita Health University School of Medicine, Aichi, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Cerebral Cortex / metabolism
Dopamine / metabolism*
Fluorescent Antibody Technique
Levodopa / metabolism*
Male
Neostriatum / cytology*,  metabolism
Nerve Fibers / metabolism*
Raphe Nuclei / metabolism
Rats
Rats, Sprague-Dawley
Serotonin / physiology*
Chemical
Reg. No./Substance:
0/Levodopa; 50-67-9/Serotonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Endogenous acetylcholine-induced Fos expression in magnocellular neurosecretory neurons in the supra...
Next Document:  Segregation of optic axons based on central target: the medial optic tract in Rana pipiens.