Document Detail


L-Carnitine supplementation for adults with end-stage kidney disease requiring maintenance hemodialysis: a systematic review and meta-analysis.
MedLine Citation:
PMID:  24368434     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: A previous meta-analysis indicated that l-carnitine significantly increased hemoglobin and decreased the required erythropoietin dose in maintenance hemodialysis patients.
OBJECTIVE: An updated systematic review and meta-analysis of randomized controlled trials (RCTs) was performed to reevaluate effects of l-carnitine.
DESIGN: The Cochrane Library, PubMed, and EMBASE databases (31 December 2012) were searched to identify RCTs that investigated effects of l-carnitine in adults with end-stage kidney disease that required maintenance hemodialysis.
RESULTS: Forty-nine RCTs (1734 participants) were included. l-Carnitine significantly decreased serum low-density lipoprotein (LDL) (mean difference: -5.82 mg/dL; 95% CI: -11.61, -0.04 mg/dL) and C-reactive protein (CRP) (-3.65 mg/L; -6.19, -1.12 mg/L). There were no significant differences in triglycerides (-0.89 mg/dL; -29.32, 27.53 mg/dL), cholesterol (0.14 mg/dL; -6.15, 6.42 mg/dL), high-density lipoprotein (1.13 mg/dL; -2.44, 4.70 mg/dL), hemoglobin (0.68 g/dL; 0.14, 1.50 g/dL), hematocrit (2.04%; -1.39, 5.48%), albumin (1.65 g/L; -0.22, 3.51 g/L), or the required erythropoietin dose (-0.76 KU/wk; -1.75, 0.23 KU/wk). No adverse effects were reported.
CONCLUSIONS: This meta-analysis failed to confirm the previous findings regarding the effects of l-carnitine on hemoglobin and the erythropoietin dose but showed that l-carnitine significantly decreased serum LDL and CRP. The extent of the decrease in LDL was not clinically relevant, whereas the significant decrease in CRP was both statistically and clinically relevant. However, the relevance of decrease in CRP with hard endpoints such as all-cause mortality and cardiovascular complications still remains to be clarified.
Authors:
Yizhi Chen; Manuela Abbate; Li Tang; Guangyan Cai; Zhixiang Gong; Ribao Wei; Jianhui Zhou; Xiangmei Chen
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Review     Date:  2013-12-24
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  99     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2014 Feb 
Date Detail:
Created Date:  2014-01-21     Completed Date:  2014-04-14     Revised Date:  2014-05-28    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  408-22     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
C-Reactive Protein / metabolism
Carnitine / administration & dosage*
Cholesterol / blood
Databases, Factual
Dietary Supplements*
Erythropoietin / blood
Hemoglobins / metabolism
Humans
Kidney Failure, Chronic / drug therapy*
Randomized Controlled Trials as Topic
Renal Dialysis*
Triglycerides / blood
Chemical
Reg. No./Substance:
0/Hemoglobins; 0/Triglycerides; 11096-26-7/Erythropoietin; 541-15-1/Carnitine; 9007-41-4/C-Reactive Protein; 97C5T2UQ7J/Cholesterol
Comments/Corrections
Erratum In:
Am J Clin Nutr. 2014 May;99(5):1143

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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