Document Detail


L-Carnitine inhibits cisplatin-induced injury of the kidney and small intestine.
MedLine Citation:
PMID:  12176057     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although cis-diamminedichloroplatinum (II) (cisplatin) is a potent anticancer drug, clinical use of this agent is highly limited predominantly because of its strong side effects on the kidney and gastrointestinal tracts. We found that cisplatin impaired respiratory function and DNA of mitochondria in renal proximal tubules and small intestinal mucosal cells, thereby inducing apoptosis of epithelial cells. Cisplatin-induced mitochondrial dysfunction and DNA (mtDNA) injury, lipid peroxidation, and apoptosis of epithelial cells in the kidney and small intestine were strongly inhibited by L-carnitine. However, carnitine had no appreciable effect on the tumoricidal action of cisplatin against cancer cells inoculated in the peritoneal cavity. These results indicate that L-carnitine may have therapeutic potential for inhibiting the side effects of cisplatin and other anticancer agents in the kidney and small intestine.
Authors:
BaoJun Chang; Manabu Nishikawa; Eisuke Sato; Kozo Utsumi; Masayasu Inoue
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of biochemistry and biophysics     Volume:  405     ISSN:  0003-9861     ISO Abbreviation:  Arch. Biochem. Biophys.     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-08-14     Completed Date:  2002-10-17     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0372430     Medline TA:  Arch Biochem Biophys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  55-64     Citation Subset:  IM    
Affiliation:
Department of Biochemistry and Molecular Pathology, Osaka City University Medical School, 1-4-3 Asahimachi, Abeno, Osaka 545-8585, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antineoplastic Agents / adverse effects,  pharmacology
Apoptosis
Carnitine / pharmacology*
Cisplatin / adverse effects,  pharmacology*
DNA / metabolism
DNA, Mitochondrial / metabolism
In Situ Nick-End Labeling
Intestine, Small / drug effects*
Kidney / drug effects*
Lipid Peroxidation
Male
Rats
Rats, Wistar
Time Factors
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/DNA, Mitochondrial; 15663-27-1/Cisplatin; 541-15-1/Carnitine; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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