| L-arginine supplementation improves exercise capacity after a heart transplant. | |
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MedLine Citation:
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PMID: 20200265 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Endothelial dysfunction is associated with the decreased exercise capacity observed in heart-transplant (HTx) recipients. L-arginine supplementation (LAS) stimulates the nitric oxide (NO) pathway and restores endothelial function. OBJECTIVE: We compared exercise capacity in healthy subjects and HTx patients and investigated whether chronic LAS might improve exercise capacity and NO/endothelin balance after an HTx. DESIGN: Clinical, echocardiographic, and exercise characteristics were measured in 11 control subjects and 22 HTx recipients. In a prospective, double-blind study, the 22 HTx recipients performed a 6-min exercise [6-min-walk test (6MWT)] and a maximal bicycle exercise test before and after a 6-wk period of placebo intake or LAS. Endothelial function was measured by analyzing blood NO metabolites, endothelin, and the resulting NO/endothelin balance. RESULTS: Exercise capacity decreased after transplantation. Unlike with the placebo intake, 6 wk of LAS improved quality of life in HTx recipients (mean +/- SEM Minnesota Score: from 15.3 +/- 1.3 to 10.6 +/- 1.1; P < 0.001) and their submaximal exercise capacity. The distance walked during the 6MWT increased (from 525 +/- 20 to 580 +/- 20 m; P = 0.002), and the ventilatory threshold during the incremental test was delayed by 1.2 min (P = 0.01). Central factors such as resting stroke volume, systolic pulmonary arterial pressure, cardiac systolodiastolic functions, and heart-rate reserve were not modified, but LAS significantly increased the NO:endothelin ratio (from 2.49 +/- 0.38 to 3.31 +/- 0.39; P = 0.03). CONCLUSION: Oral LAS may be a useful adjuvant therapeutic to improve quality of life and exercise tolerance in HTx recipients. |
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Authors:
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St?phane Doutreleau; Olivier Rouyer; Paola Di Marco; Evelyne Lonsdorfer; Ruddy Richard; Fran?ois Piquard; Bernard Geny |
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Publication Detail:
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Type: Journal Article Date: 2010-03-03 |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 91 ISSN: 1938-3207 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-21 Completed Date: 2010-05-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 1261-7 Citation Subset: AIM; IM |
Affiliation:
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Medicine Faculty, Physiology Institute, Strasbourg, France. stephane.doutreleau@chru-strasbourg.fr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arginine
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administration & dosage,
blood,
therapeutic use* Blood Pressure / drug effects Cyclosporine / blood Dietary Supplements Double-Blind Method Echocardiography Endothelin-1 / blood Endothelins / blood Exercise Test / methods Exercise Tolerance / physiology* Heart Rate / drug effects Heart Transplantation / physiology* Humans Immunosuppressive Agents / blood, therapeutic use Middle Aged Nitric Oxide / blood Patient Selection Placebos Pulmonary Artery / drug effects, physiology, physiopathology Quality of Life |
| Chemical | |
Reg. No./Substance:
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0/Endothelin-1; 0/Endothelins; 0/Immunosuppressive Agents; 0/Placebos; 10102-43-9/Nitric Oxide; 59865-13-3/Cyclosporine; 74-79-3/Arginine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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