Document Detail

L-Arginine reverses the abolition of hypovolaemic decompensation by N-nitro-L-arginine methyl ester and naloxone in conscious rabbits.
MedLine Citation:
PMID:  8750696     Owner:  NLM     Status:  MEDLINE    
Graded caval occlusion in conscious rabbits caused a biphasic haemodynamic response. Phase I was characterized by a fall in systemic vascular conductance so that arterial pressure was maintained. When cardiac output had fallen to 65 +/- 2% of its baseline level, phase II supervened. During phase II, conductance rose abruptly and arterial pressure fell to a life-threatening level (< or = 40 mm Hg). Fourth ventricular administration of either N-nitro-L-arginine methyl ester or naloxone prevented the occurrence of phase II. Fourth ventricular administration of L-arginine had no effect on the response to graded caval occlusion but was able to reverse the phase II blocking action of N-nitro-L-arginine methyl ester and naloxone. It is concluded that central nitrergic and opioid mechanisms interact to cause the vasodilatation characteristic of the decompensatory phase II of the cardiovascular response to acute hypovolaemia.
S Ventura; J Ludbrook
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  294     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-10-23     Completed Date:  1996-10-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  369-75     Citation Subset:  IM    
University of Melbourne Department of Surgery, Royal Melbourne Hospital, Parkville, Victoria, Australia.
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MeSH Terms
Arginine / analogs & derivatives*,  pharmacology*
Enkephalin, D-Penicillamine (2,5)-
Enkephalins / pharmacology
Hemodynamics / drug effects*
Hemorrhage / physiopathology*
NG-Nitroarginine Methyl Ester
Naloxone / pharmacology*
Narcotic Antagonists / pharmacology*
Nitric Oxide / physiology*
Nitric Oxide Synthase / antagonists & inhibitors*
Shock, Hemorrhagic / prevention & control
Reg. No./Substance:
0/Enkephalins; 0/Narcotic Antagonists; 10102-43-9/Nitric Oxide; 465-65-6/Naloxone; 50903-99-6/NG-Nitroarginine Methyl Ester; 74-79-3/Arginine; 88373-73-3/Enkephalin, D-Penicillamine (2,5)-; EC Oxide Synthase

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