| L-Arginine normalizes coronary vasomotion in long-term smokers. | |
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MedLine Citation:
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PMID: 9927394 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Noninvasive measurements of myocardial blood flow (MBF) with PET revealed an abnormal coronary vasomotor response to cold pressor test in healthy long-term smokers. If coronary endothelial dysfunction accounted for this abnormality, we hypothesized that it could be reversed by L-arginine as the substrate for NO synthase. METHODS AND RESULTS: MBF was quantified with 13N-labeled ammonia and PET in 11 healthy smokers (age, 45+/-10 years; 27+/-10 years of smoking) and in 12 age-matched nonsmokers on 2 separate days. On day 1, MBF was measured at rest and, after intravenous L-arginine, during cold pressor test. On day 2, MBF was measured during cold pressor test and then at rest during L-arginine. Baseline rate-pressure product (RPP) (6559+/-1590 versus 7144+/-1157 bpmxmm Hg) and MBF (0.65+/-0.14 versus 0.73+/-0.13 mL x g-1 x min-1) were similar in nonsmokers and smokers. Cold pressor test increased RPP similarly in both groups (53+/-26% versus 46+/-26%), whereas MBF increased in nonsmokers (to 0.93+/-0.25 mL x g-1 x min-1; P<0.05) but not in smokers (0.80+/-0.16 mL x g-1 x min-1). The percent MBF increase differed between nonsmokers and smokers (44+/-25% versus 11+/-14%; P=0.0017). However, after L-arginine, the magnitude of MBF response to cold pressor test no longer differed between groups (48+/-36% versus 48+/-28%), whereas RPP again increased similarly in the 2 groups (59+/-30% versus 44+/-16%). L-Arginine had no effect on resting MBF in smokers or nonsmokers. CONCLUSIONS: Our findings implicate the coronary endothelium as the major site of the abnormal vasomotor response in long-term smokers. Cold pressor test combined with PET imaging may allow the noninvasive identification of coronary endothelial dysfunction in humans. |
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Authors:
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R Campisi; J Czernin; H Sch?der; J W Sayre; H R Schelbert |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Circulation Volume: 99 ISSN: 0009-7322 ISO Abbreviation: Circulation Publication Date: 1999 Feb |
Date Detail:
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Created Date: 1999-03-09 Completed Date: 1999-03-09 Revised Date: 2010-03-24 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 491-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Molecular and Medical Pharmacology, UCLA School of Medicine, and Laboratory of Structural Biology and Molecular Medicine, University of California, Los Angeles, 90095-1735, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Arginine / pharmacology* Blood Flow Velocity / drug effects Case-Control Studies Cold Temperature / diagnostic use Confounding Factors (Epidemiology) Coronary Circulation / drug effects* Coronary Vessels / drug effects*, physiopathology*, radionuclide imaging Endothelium, Vascular / drug effects* Female Hemodynamics / drug effects* Humans Male Middle Aged Nitrogen Radioisotopes / diagnostic use Smoking / physiopathology* Time Factors Tomography, Emission-Computed / methods Vascular Resistance / drug effects Vasoconstriction / drug effects Vasodilation / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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HL-33177/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Nitrogen Radioisotopes; 74-79-3/Arginine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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